Figure 1
From: Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors
Many of the methylation changes at single probes between cancer and normal are far from CpG islands. (A-C) Scatter graph of individual probe average values in normal (x-axis) and cancer (y-axis) for island (A), shore (B), and open sea (C) probes. A random sampling of 10,000 probes is used for each region to illustrate the pattern. Panels A-C, D-F, G-I, J-L, M-O, P-R correspond to breast, colon, lung, pancreas adenocarcinoma, pancreas neuroendocrine tumor, and thyroid, respectively.