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Table 5 Genes differentially expressed in common among colon cancer cell lines resistant to MTX

From: Networking of differentially expressed genes in human cancer cells resistant to methotrexate

GenBank

Gene name

Description

Ratio MIA PaCa-2

Ratio K562

Ratio Saos-2

BC003584

DHFR

Dihydrofolate reductase

16.97

17.78

4.06

BC000192

DHFR

Dihydrofolate reductase

12.56

13.57

5.28

AI144299

DHFR

Dihydrofolate reductase

12.1

9.45

8.94

NM_000791

DHFR

Dihydrofolate reductase

9.66

6.76

5.57

BE622627

PIK3R3

Phosphoinositide-3-kinase, regulatory subunit 3

5.23

2.09

4.44

AW469790

EEF1A1

Eukaryotic translation elongation factor 1 alpha 1

2.29

2.75

2.05

NM_012446

SSBP2

Single-stranded DNA binding protein 2

2.2

5.04

2.03

AF318326

APG10L

ATG10 autophagy related 10 homolog

2.08

7.39

2.19

  1. Genes differentially expressed by at least twofold with a P-value < 0.05 including multiple testing correction were compared between MIA PaCa-2, K562 and Saos-2 cells as described in Table 3.