Table 3 Characteristics of the samples used from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
Hormones | Breast cancer (#Samples) | Methylation signature | P value | |
|---|---|---|---|---|
| Â | Â | Positive (SD) | Negative (SD) | Â |
Mean oestradiol, pg/mL | Yes (65) | 20.51 (16.74) | 18.67 (10.09) | 0.59 |
| Â | No (115) | 17.36 (8.32) | 19.24 (8.11) | 0.22 |
Mean free oestradiol, pmol/L | Yes (65) | 0.98 (0.58) | 0.99 (0.55) | 0.95 |
| Â | No (114) | 0.84 (0.43) | 1.02 (0.59) | 0.05 |
Mean oestrone, pg/mL | Yes (67) | 126.7 (156.59) | 97.22 (58.10) | 0.31 |
| Â | No (117) | 112.7 (91.86) | 97.55 (92.41) | 0.38 |
Mean androstendione, nmol/L | Yes (64) | 3.35 (1.66) | 3.96 (2.00) | 0.19 |
| Â | No (118) | 3.4 (2.10) | 3.13 (1.41) | 0.41 |
Mean testosterone, nmol/L | Yes (65) | 0.30 (0.17) | 0.35 (0.20) | 0.3 |
| Â | No (115) | 0.28 (0.17) | 0.31 (0.19) | 0.42 |
Mean free testosterone, ng/dl | Yes (65) | 0.12 (0.08) | 0.14 (0.10) | 0.35 |
| Â | No (115) | 0.11 (0.07) | 0.13 (0.09) | 0.17 |
Mean SHBG, nmol/L | Yes (66) | 57.54 (37.71) | 49.79 (19.86) | 0.24 |
| Â | No (116) | 61.26 (26.46) | 54.49 (24.36) | 0.16 |
Mean progesterone, ng/mL | Yes (66) | 0.63 (2.13) | 0.28 (0.21) | 0.34 |
| Â | No (114) | 0.27 (0.17) | 0.28 (0.16) | 0.84 |
Mean DHEAS, ug/dl | Yes (66) | 109.6 (57.54) | 92.52 (56.75) | 0.23 |
| Â | No (116) | 115.8 (65.49) | 107.1 (57.92) | 0.45 |
Mean ER alpha, pg/mL | Yes (67) | 89.67 (87.33) | 81.23 (56.48) | 0.64 |
| Â | No (120) | 69.54 (62.56) | 75.29 (61.84) | 0.61 |
Mean ER beta, pg/mL | Yes (67) | 87.06 (122.37) | 64.01 (75.85) | 0.35 |
| Â | No (120) | 56.74 (62.83) | 60.95 (72.14) | 0.73 |
Mean AR, ng/mL | Yes (67) | 2.5 (0.95) | 2.4 (0.91) | 0.78 |
| Â | No (119) | 2.28 (1.11) | 2.45 (0.96) | 0.37 |