A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival

Table 1 Characteristics of the samples used from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

Factors		Methylation signature		P value
		Positive	Negative
OCP use in the past	Yes	72	60	0.604
	No	55	54
Pregnancies <6 months	Yes	32	35	0.387
	No	95	78
Pregnancies >6 months	Yes	109	102	0.439
	No	18	12
Mother breast cancer	Yes	14	11	0.833
	No	113	103
Grandmother(s) breast cancer	Yes	2	7	0.0887
	No	125	107
Sister(s) breast cancer	Yes	5	11	0.118
	No	122	103
Aunt(s) breast cancer	Yes	12	6	0.233
	No	115	108
Any family member breast cancer	Yes	29	32	0.376
	No	98	82
Alcohol units per week	Yes	78	68	1
	No	26	23
Smoker	Yes	41	37	0.89
	No	84	72

The samples were categorised according to their individual risk scores. These risk scores are the product of the methylation profile with the regression coefficients of the signature. The statistical significance was assessed by a two-sided, Fisher’s exact test. The missing values were excluded from the analysis.

ISSN: 1756-994X