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Figure 2 | Genome Medicine

Figure 2

From: DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes

Figure 2

Mutational patterns of typical tumor suppressor genes and oncogenes. (A) Mutations of APC in colorectal cancer. This is the mutational landscape of a typical TSG with diffuse truncating mutations (in red) and a non-specific pattern of missense mutations (blue density plots). Truncating mutations cover 85% of all the non-synonymous mutations on APC. (B) Mutations of KRAS in colorectal cancer. This is the mutational landscape of a typical OG with significant clusters of mutations that are present in specific hot spots of the protein ideogram (blue density plots). In particular, KRAS tends to mutate on amino acids 12 and 13 (119/143 mutations). The total numbers of truncating sites and missense mutations are indicated in the panels. The mutations are mapped on the corresponding canonical protein ideogram, and not all the mutations can thus be represented (for example, splice site mutations are not included in the figure).

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