From: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin
Gene | N. MNA mutated | FRRa | Fraction of samples mutated (MNA | CRCb) | Link to oncogenesis |
---|---|---|---|---|
KRAS | 10 | 0 | 1 | 0.42 | Cancer Gene Census: pancreatic, colorectal, lung |
GNAS | 9 | 0 | 0.9 | 0.06 | Cancer Gene Census: pituitary tumors |
POM121L12 | 2 | 0 | 0.2 | 0.02 | Â |
DOK6 | 2 | 0 | 0.2 | 0.02 | RET signaling |
IRX6 | 2 | 0.001 | 0.2 | 0.02 | Homeobox TF neurogenesis |
KRT37 | 2 | 0.001 | 0.2 | 0.02 | Â |
EEF1A1 | 2 | 0.003 | 0.2 | 0.01 | Proto-oncogene of PTI1: Prost. Tumor Inducing 1 |
CRY2 | 2 | 0.003 | 0.2 | 0.01 | Â |
SMAD2 | 2 | 0.004 | 0.2 | 0.04 | TFGβ pathway |
SNTG1 | 2 | 0.004 | 0.2 | 0.02 | Â |
OCA2 | 2 | 0.007 | 0.2 | 0.03 | Â |
EPHA10 | 2 | 0.007 | 0.2 | 0.02 | Receptor for EPH pathway |
ZNF512B | 2 | 0.008 | 0.2 | 0.03 | Â |
PTCHD3 | 2 | 0.009 | 0.2 | 0.04 | Homologous to PTCH1: Shh receptor |
ANKRD24 | 2 | 0.009 | 0.2 | 0.02 | Â |
DCLK1 | 2 | 0.011 | 0.2 | 0.05 | Intestinal tumor stem cell marker |
PCDH10 | 2 | 0.011 | 0.2 | 0.09 | Silenced in multiple epithelial cancers |
MTIF2 | 2 | 0.014 | 0.2 | 0.02 | Â |
ITGA11 | 2 | 0.014 | 0.2 | 0.02 | Â |
COL5A3 | 2 | 0.014 | 0.2 | 0.04 | Â |
PCDH17 | 2 | 0.015 | 0.2 | 0.08 | Mutated and silenced in GI cancer |
CNTNAP2 | 2 | 0.018 | 0.2 | 0.06 | Tumor suppressor in Gliomas |
TRPS1 | 2 | 0.022 | 0.2 | 0.09 | GATA factor involved in EMT in breast cancer |
ABCA7 | 2 | 0.04 | 0.2 | 0.06 | Â |
FAT4 | 3 | 0.045 | 0.3 | 0.2 | Putative receptor of Hippo pathway |
DOCK3 | 2 | 0.061 | NA | Â |
ZNF469 | 2 | 0.067 | NA | Â |
SPTA1 | 2 | 0.068 | NA | Â |
COL6A3 | 2 | 0.089 | NA | Â |
LAMA1 | 2 | 0.105 | NA | Â |
APOB | 2 | 0.261 | NA | Â |
CSMD1 | 2 | 0.305 | NA | Â |
MUC16 | 2 | 0.659 | NA | Â |
TTN | 2 | 0.992 | NA | Â |