Figure 3From: Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivityCoexpression subnetworks for each of the Pareto optimal genes. (a) Genes in untreated tumor samples. (b) Genes in letrozole-treated tumor samples. Due to their numbers of positive and negative coexpression partners, GTPBP4, CD200, MID1, FAT4, and NEFL, are likely important for maintaining the tumor phenotype in an estrogen-rich environment. Targeting one or more of these genes concurrently with letrozole treatment may have a synergistic effect resulting in further reductions in tumor volume. Following a 90-day course of letrozole treatment, the number and identity of coexpression partners of these genes changed, illustrating the context-dependent nature of gene–gene associations and suggesting these genes are not as important in an estrogen-depleted environment. Dotted lines indicate negative relationships.Back to article page