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Figure 3 | Genome Medicine

Figure 3

From: Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivity

Figure 3

Coexpression subnetworks for each of the Pareto optimal genes. (a) Genes in untreated tumor samples. (b) Genes in letrozole-treated tumor samples. Due to their numbers of positive and negative coexpression partners, GTPBP4, CD200, MID1, FAT4, and NEFL, are likely important for maintaining the tumor phenotype in an estrogen-rich environment. Targeting one or more of these genes concurrently with letrozole treatment may have a synergistic effect resulting in further reductions in tumor volume. Following a 90-day course of letrozole treatment, the number and identity of coexpression partners of these genes changed, illustrating the context-dependent nature of gene–gene associations and suggesting these genes are not as important in an estrogen-depleted environment. Dotted lines indicate negative relationships.

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