Skip to main content
Figure 1 | Genome Medicine

Figure 1

From: Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivity

Figure 1

Gene-wise patterns of connectivity reveal essential genes as potential drug targets for combination treatment with letrozole. Using Pareto optimization we identified the set of genes that fall along the Pareto front denoted by the dashed lines in the (a) untreated and (b) letrozole-treated tumor samples. These are the genes that have the optimal balance of positive and negative connections, a property that has been associated with essentiality.

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us