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Table 1 Characteristics of screened compounds

From: A genome scale overexpression screen to reveal drug activity in human cells

Drug name

Screen concentration

Category*

Clinical use

Known target(s)

Reference

Methotrexate

60 nM

Antimetabolites/ immunosuppressants

Antineoplastic

DHFR

[20]

Antirheumatic

Dermatologic agent

Aminopterin

20 nM

Antimetabolites (discontinued)

Dermatologic agent (phase I)

DHFR, FPGS(?)

[21]

Antineoplastic agent (phase II)

Orlistat

20 μM

Antiobesity preparations, excluding diet products

Anti-obesity agent

LPL

[22]

PNLIP

[23]

FASN

Bleomycin

1 μM

Cytotoxic antibiotics and related substances

Antineoplastic agent

DNA

[24]

LIG1

LIG3

Cisplatin

2 μM

Other antineoplastic agents

Antineoplastic agent

DNA

[25]

Mitomycin C

80 nM

Cytotoxic antibiotics and related substances

Antineoplastic agent

DNA

[26]

17_DMAG

70 nM

Experimental Hsp90 inhibitor

Antineoplastic agent (phases I and II)

Hsp90

[27]

HSP90AA1

HSP90AA2

HSP90B1

HSP90AB1