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Figure 2 | Genome Medicine

Figure 2

From: Transcriptional dissection of pancreatic tumors engrafted in mice

Figure 2

PDAC and HCC PDX models show transcriptional differences that are not observed in tumor-derived cell lines. (A) First two dimensions of the gene expression space of PDAC and HCC PDX models and primary tumors (see all three dimensions in Figure S3 in Additional file1). This panel represents the result of an optimized iterative k-means clustering, where the optimal number of groups is k = 4. Each line joins a sample with the centroid of its cluster. (B) Gene expression space of PDAC and HCC cell lines and primary tumors. Optimal k-means clustering for k = 3. Each line joins a sample with the centroid of its cluster. The points are colored by type of sample class. See PCA results in Figure S4 and alternative clustering strategies in Figures S5 and S6 in Additional file1.

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