Figure 1

MCA gene expression spaces from PDAC and HCC. (A) PDAC gene expression space. (B) HCC gene expression space. The percentage of variance explained by each axis is indicated between parentheses. Each point represents the expression pattern from a sample. Grey lines represent the resulting clusters from k-means clustering for k = 3 (selected as the optimal clustering result; see Materials and methods). Each line joins a sample with the centroid of its cluster. (A) In pancreas, all PDX models and cell lines were derived from adenocarcinomas. (B) In liver, all samples came from carcinomas, except two cell lines that were derived from hepatoblastomas. See text for details. See Figures S1 and S2 in Additional file1 for additional results using PCA and hierarchical clustering.