Table 1 Association summary statistics
Locus & SNP (effect/other allele) | Metabolite | Meta-analysis | KORA | TwinsUK | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Beta | (SE) | P value | Beta | (SE) | P value | Beta | (SE) | P value |
GCKR rs1260326 (T/C) | PC aa C40:5 | 0.037 | (0.008) | 1.26 × 10−6 | 0.032 | (0.009) | 3.19 × 10−4 | 0.047 | (0.014) | 8.09 × 10−4 |
LPA rs1564348 (T/C) | C3 | 0.053 | (0.011) | 4.94 × 10−7 | 0.049 | (0.013) | 1.15 × 10−4 | 0.062 | (0.019) | 1.24 × 10−3 |
C8:1 | 0.09 | (0.017) | 6.28 × 10−8 | 0.064 | (0.02) | 1.60 × 10−3 | 0.143 | (0.029) | 4.86 × 10−7 | |
FADS1 rs174546 (T/C) | PC aa C32:0 | −0.038 | (0.006) | 3.69 × 10−10 | −0.039 | (0.007) | 4.21 × 10−8 | −0.036 | (0.012) | 1.70 × 10−3 |
|  | PC aa C32:2 | 0.072 | (0.012) | 5.15 × 10−9 | 0.091 | (0.017) | 9.24 × 10−8 | 0.051 | (0.018) | 5.60 × 10−3 |
|  | PC aa C34:2 | 0.038 | (0.005) | 2.03 × 10−13 | 0.037 | (0.006) | 2.13 × 10−10 | 0.044 | (0.012) | 1.82 × 10−4 |
|  | PC aa C34:3 | 0.041 | (0.008) | 8.24 × 10−7 | 0.04 | (0.01) | 5.15 × 10−5 | 0.042 | (0.015) | 5.08 × 10−3 |
|  | PC aa C34:4 | −0.100 | (0.01) | 1.45 × 10−23 | −0.106 | (0.012) | 3.24 × 10−17 | −0.09 | (0.017) | 7.61 × 10−8 |
|  | PC aa C36:2 | 0.043 | (0.006) | 6.32 × 10−14 | 0.045 | (0.006) | 3.75 × 10−12 | 0.034 | (0.012) | 4.01 × 10−3 |
|  | PC aa C36:3 | 0.055 | (0.006) | 5.48 × 10−19 | 0.053 | (0.007) | 1.13 × 10−13 | 0.058 | (0.012) | 3.38 × 10−6 |
|  | PC aa C36:4 | −0.113 | (0.006) | 6.36 × 10−69 | −0.112 | (0.007) | 1.21 × 10−48 | −0.116 | (0.013) | 1.49 × 10−19 |
|  | PC aa C36:5 | −0.129 | (0.012) | 8.72 × 10−26 | −0.143 | (0.016) | 8.29 × 10−20 | −0.105 | (0.02) | 1.12 × 10−7 |
|  | PC aa C36:6 | −0.054 | (0.011) | 1.52 × 10−6 | −0.051 | (0.014) | 2.34 × 10−4 | −0.059 | (0.019) | 1.82 × 10−3 |
|  | PC aa C38:4 | −0.138 | (0.007) | 6.22 × 10−83 | −0.136 | (0.008) | 5.47 × 10−56 | −0.144 | (0.014) | 2.14 × 10−26 |
|  | PC aa C38:5 | −0.106 | (0.007) | 4.79 × 10−51 | −0.108 | (0.008) | 4.48 × 10−36 | −0.102 | (0.013) | 2.14 × 10−14 |
|  | PC aa C40:4 | −0.075 | (0.008) | 9.54 × 10−20 | −0.075 | (0.01) | 6.79 × 10−14 | −0.076 | (0.015) | 2.14 × 10−7 |
|  | PC aa C40:5 | −0.075 | (0.008) | 2.29 × 10−21 | −0.075 | (0.01) | 8.02 × 10−15 | −0.075 | (0.014) | 1.18 × 10−7 |
|  | PC aa C40:6 | −0.050 | (0.009) | 1.21 × 10−7 | −0.045 | (0.012) | 9.55 × 10−5 | −0.058 | (0.016) | 2.74 × 10−4 |
|  | PC aa C42:0 | −0.042 | (0.009) | 1.14 × 10−6 | −0.035 | (0.01) | 7.54 × 10−4 | −0.055 | (0.015) | 2.13 × 10−4 |
|  | PC aa C42:1 | −0.065 | (0.008) | 6.13 × 10−15 | −0.062 | (0.01) | 4.31 × 10−10 | −0.075 | (0.016) | 2.12 × 10−6 |
|  | PC aa C42:4 | −0.065 | (0.007) | 1.82 × 10−20 | −0.064 | (0.007) | 1.15 × 10−17 | −0.067 | (0.02) | 6.77 × 10−4 |
|  | PC aa C42:6 | −0.050 | (0.007) | 3.05 × 10−14 | −0.05 | (0.008) | 2.70 × 10−10 | −0.05 | (0.012) | 4.05 × 10−5 |
|  | PC ae C36:2 | 0.060 | (0.008) | 1.58 × 10−15 | 0.07 | (0.009) | 5.04 × 10−15 | 0.034 | (0.014) | 1.41 × 10−2 |
|  | PC ae C36:3 | 0.069 | (0.007) | 1.11 × 10−22 | 0.076 | (0.008) | 1.87 × 10−19 | 0.051 | (0.013) | 8.28 × 10−5 |
|  | PC ae C36:4 | −0.066 | (0.007) | 9.79 × 10−20 | −0.058 | (0.009) | 2.46 × 10−11 | −0.082 | (0.013) | 1.08 × 10−10 |
|  | PC ae C36:5 | −0.096 | (0.008) | 1.22 × 10−37 | −0.088 | (0.009) | 1.09 × 10−22 | −0.116 | (0.014) | 3.38 × 10−17 |
|  | PC ae C38:4 | −0.081 | (0.006) | 8.79 × 10−40 | −0.076 | (0.007) | 5.96 × 10−26 | −0.094 | (0.012) | 2.11 × 10−14 |
|  | PC ae C38:5 | −0.076 | (0.006) | 1.72 × 10−34 | −0.071 | (0.007) | 1.30 × 10−21 | −0.092 | (0.012) | 5.76 × 10−15 |
|  | PC ae C38:6 | −0.047 | (0.007) | 1.95 × 10−10 | −0.041 | (0.009) | 2.91 × 10−6 | −0.063 | (0.014) | 3.93 × 10−6 |
|  | PC ae C40:1 | −0.062 | (0.008) | 8.54 × 10−17 | −0.067 | (0.009) | 1.85 × 10−14 | −0.049 | (0.015) | 9.82 × 10−4 |
|  | PC ae C40:4 | −0.066 | (0.006) | 1.60 × 10−25 | −0.064 | (0.007) | 3.23 × 10−20 | −0.076 | (0.016) | 1.38 × 10−6 |
|  | PC ae C40:5 | −0.065 | (0.006) | 2.60 × 10−26 | −0.063 | (0.007) | 1.38 × 10−19 | −0.076 | (0.014) | 4.91 × 10−8 |
|  | PC ae C40:6 | −0.036 | (0.008) | 2.14 × 10−6 | −0.029 | (0.009) | 9.86 × 10−4 | −0.051 | (0.014) | 1.67 × 10−4 |
|  | PC ae C42:1 | −0.048 | (0.008) | 2.12 × 10−9 | −0.047 | (0.009) | 7.56 × 10−8 | −0.052 | (0.02) | 8.09 × 10−3 |
|  | PC ae C42:5 | −0.062 | (0.006) | 1.74 × 10−22 | −0.057 | (0.008) | 4.97 × 10−14 | −0.075 | (0.012) | 1.59 × 10−9 |
|  | PC ae C44:5 | −0.071 | (0.008) | 1.08 × 10−19 | −0.066 | (0.009) | 2.49 × 10−12 | −0.081 | (0.014) | 6.64 × 10−9 |
|  | PC ae C44:6 | −0.079 | (0.008) | 6.01 × 10−23 | −0.075 | (0.01) | 3.47 × 10−14 | −0.088 | (0.014) | 1.58 × 10−10 |