Figure 6

Change in transcription factor motif binding prediction within s-DMRs between primates calculated via TRAP [[55]] with TRANSFAC motifs[56]. (A,B) Difference in binding prediction (total corrected Benjamini-Hochberg -log₁₀P-value) between human and chimpanzee (y-axis) and human and rhesus macaque (x-axis) for each motif within the total set of hypomethylated (A) and hypermethylated (B) CpGi s-DMRs. Known TFBSs with MDR effects are highlighted in color (SP1 in red, CTCF in blue, RFX motif family in green). Both CTCF motifs show a consistent increase in the hypomethylated s-DMRs, as well as a consistent decrease in the hypermethylated DMRs, with respect to human. The MeCP2 motif is identified as a strongly increased outlier in the hypermethylated s-DMRs (orange).