Table 2 Proteins unchanged at P1 but decreased >50% or 20 to 50% at P5 in the rostral band of LAL muscle from SMA mice compared with littermate controls
Gene name | Protein name | Accession number | Peptides at P5 | Ratio KO/control at P1 | Ratio KO/control at P5 | Score at P5 | Anova ( P-value) at P5 |
|---|---|---|---|---|---|---|---|
Rrbp1 | Ribosome-binding protein 1 | RRBP1_MOUSE | 3 | 0.89 | 0.15 | 60.23 | 1.97E-05 |
Tpm1 | Tropomyosin alpha-1 chain | TPM1_MOUSE | 6 | 0.92 | 0.25 | 652.67 | 6.87E-06 |
Actn2 | Alpha-actinin-2 | ACTN2_MOUSE | 15 | 0.89 | 0.61 | 1413.57 | 1.82E-04 |
Tcpb | T-complex protein 1 subunit beta | TCPB_MOUSE | 3 | 0.89 | 0.66 | 162.09 | 2.07E-03 |
Postn | Periostin | POSTN_MOUSE | 3 | 0.99 | 0.70 | 142.66 | 7.55E-04 |
Hs90a | Heat shock protein HSP 90-alpha | HS90A_MOUSE | 3 | 0.99 | 0.70 | 326.05 | 7.71E-04 |
Hs90b | Heat shock protein HSP 90-beta | HS90B_MOUSE | 8 | 0.90 | 0.70 | 600.51 | 6.45E-05 |
Rtn4 | Reticulon-4 | RTN4_MOUSE | 5 | 0.86 | 0.79 | 123.82 | 1.69E-02 |
Nb5r3 | NADH-cytochrome b5 reductase 3 | NB5R3_MOUSE | 3 | 0.95 | 0.79 | 65.43 | 3.90E-05 |