Table 6 Recommendations for applying consensus results to somatic mutation predictions
From: A simple consensus approach improves somatic mutation prediction accuracy
Prediction set | Recommendations |
|---|---|
Consensus | Accurate, high-confidence predictions suitable for further analysis |
Partial consensus | Roughly equal numbers of genuine somatic mutations and false positives. Utility dependent on need to maximize sensitivity. Further filtering can be performed to improve confidence |
No consensus | Largely false positives; may be disregarded unless compelling biological interest exists. Explore using high-confidence list of variants from consensus |