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Figure 3 | Genome Medicine

Figure 3

From: Serum acute phase reactants hallmark healthy individuals at risk for acetaminophen-induced liver injury

Figure 3

Sections of two-dimensional electrophoresis gels showing regulated serum proteins from healthy volunteers. (A) ALT responders, ALT non-responders, placebo prior to APAP or placebo treatment (day 0, left panel, I) and after daily APAP treatment for 7 days (right panel, II). A1AT, alpha-1-antiproteinase; ApoA1, apolipoprotein A-I; Hpt, haptoglobin; TTR, transthyretin; RBP4, retinol binding protein 4; ApoH, apolipoprotein H. (B) Results from densitometric scans of two-dimensional electrophoresis images of serum proteins regulated in DILI responders, non-responders and placebo-treated healthy volunteers prior to APAP treatment. (C) Results from densitometric scans of two-dimensional electrophoresis images of serum proteins regulated in DILI responders, non-responders and placebo-treated healthy volunteers after APAP treatment for 7 days. (D) Results from densitometric scans of two-dimensional electrophoresis images of serum proteins after immunodepletion of high abundance proteins in DILI responders, non-responders and placebo-treated healthy volunteers after APAP treatment for 7 days. ***P < 0.001; **P < 0.01; *P < 0.05.

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