From: Incremental value of rare genetic variants for the prediction of multifactorial diseases
OR | Frequency | Variants (n) | AUC | IDI | NRI(>0.01) | Â | NRI categorical | Â | ||
---|---|---|---|---|---|---|---|---|---|---|
 |  |  | Genetic | Combined | Δ |  |  | Total | Cases | Controls |
Rare variants | Â | Â | Â | Â | Â | Â | Â | Â | ||
2 | 0.0001 | 1 | 0.50 | 0.76 | 0 | 0 | 0 | 0 | 0 | 0 |
 | 0.001 | 1 | 0.50 | 0.76 | 0 | 0 | 0 | 0 | 0 | 0 |
 | 0.005 | 1 | 0.50 | 0.76 | 0 | 0 | -0.01 | 0 | 0 | 0 |
 | 0.01 | 1 | 0.51 | 0.76 | 0 | 0 | -0.03 | 0 | 0 | 0 |
5 | 0.0001 | 1 | 0.50 | 0.76 | 0 | 0 | 0 | 0 | 0 | 0 |
 | 0.001 | 1 | 0.50 | 0.76 | 0 | 0 | -0.01 | 0 | 0 | 0 |
 | 0.005 | 1 | 0.51 | 0.76 | 0 | 0 | -0.05 | 0.01 | 0.01 | 0 |
 | 0.01 | 1 | 0.52 | 0.77 | 0.01 | 0.01 | -0.10 | 0.02 | -0.01 | 0.03 |
10 | 0.0001 | 1 | 0.50 | 0.76 | 0 | 0 | 0 | 0 | 0 | 0 |
 | 0.001 | 1 | 0.50 | 0.76 | 0 | 0 | -0.03 | 0.00 | 0 | 0.01 |
 | 0.005 | 1 | 0.52 | 0.77 | 0.01 | 0.02 | -0.11 | 0.02 | -0.01 | 0.03 |
 | 0.01 | 1 | 0.54 | 0.78 | 0.02 | 0.03 | -0.13 | 0.04 | -0.02 | 0.06 |
Common variants | Â | Â | Â | Â | Â | Â | Â | Â | ||
1.14-1.45 a | 0.03-0.84* | 10 | 0.59 | 0.77 | 0.01 | 0.01 | 0.20 | 0.04 | 0.01 | 0.04 |