Whole genome sequencing in support of wellness and health maintenance

Table 2 Genetic predictions and clinical phenotypes related to metabolic and cardiovascular disorders

Sample ID	Common variant prediction	Clinical phenotype	Clinical risk factors
CHD-1	T2D (4.5)	-	FMD, CD34+ cells
CHD-2	T2D (3.8); MI (1.24)^a	-	BP, N:L ratio, SEVR, HDL-C
CHD-3	Stroke (2.18); CAD (1.21) ^a; obesity (1.23)^b	Obese	Total cholesterol, TG, BP, N:L ratio, FMD, PWV, FRS (CVD)
CHD-4	T2D (1.20); CAD (1.32) ^a	-	SEVR, N:L ratio, hyperemia, CD34+ cells
CHD-5	CAD (2.09)^a; T2D (2.24); stroke (2.18); MI (1.91)^a	-	Total cholesterol, LDL-C, SEVR, hyperemia, AIX, PWV
CHD-6	Hypertriglyceridemia (3.48)^b; atrial fibrillation (1.35)	Hypertriglyceridemia	HDL-C, SEVR, CD34+ cells
CHD-7	Stroke (2.18)^b; MI (1.70); atrial fibrillation (1.35); CAD (1.40)	Stroke	FMD, CD34+ cells
CHD-8	Hypertriglyceridemia (1.72)^b; CAD (1.38)^a	Hypertriglyceridemia	WHR, glucose, FRS (T2D), total cholesterol, LDL-C, BP, AIX, PWV, FMD

Abbreviations: AIX: Augmentation Index; BP: blood pressure; CAD: coronary artery disease; CVD: cardiovascular disease; FMD: flow-mediated dilation; FRS: Framingham Risk Scores; HDL: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; MI: myocardial infarction; N:L: neutrophil:lympocyte; SEVR: sub-endocardial viability ratio; T2D: Type 2 diabetes; TG: triglycerides; PWV: pulse wave velocity;. Numbers in brackets indicate LR due to genetic variants. ^aconcordance with clinical risk factors, ^bconcordance with clinical phenotype.

ISSN: 1756-994X