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Figure 5 | Genome Medicine

Figure 5

From: Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors

Figure 5

Validation of detected copy number alterations of Cyclin D1 (CCND1 ) by immunohistochemistry. Staining of HNSCC samples for Cyclin D1 confirmed strong expression in eight of nine CCND1 amplified cases (and intermediate expression in the remaining case) compared with samples harboring no copy number alteration; Representative samples shown: Low levels of CCND1 expression in the tumor tissue of sample 'P38_pos' (A) and sample 'P29_neg' (B); NGS: No CNA; High levels of Cyclin D1 expression in the tumor tissue of sample 'P12_neg' (C) and sample 'P17_neg' (D); NGS: CCND1 copy number gain.

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Genome Medicine

ISSN: 1756-994X

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