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Table 4 Summary of module characterization and trait association

From: Genes and pathways underlying regional and cell type changes in Alzheimer's disease

Module

Characterization

Trait association

Black

Astrocyte

Up with AD

Blue

Mitochondria, neuron

Down with AD

Brown

Pyramidal neuron

Down with AD duration, down with AD, enriched CA3

Cyan

Glutatmatergic synapse, neuron

Down with AD, down with age, enriched in CA3

Green

Astrocyte (and other glia), cell death?

Up with AD

Green-yellow

Ribosome, oligodendrocyte

---

Grey60

Microglia (M8)?

Up with AD

Light cyan

Astrocyte

Enriched in CA1

Light green

Microglia (M10)

Enriched in CA1, up with NFTs in CT, up with AD

Light yellow

Pval+ interneuron

Down with AD, enriched in CA1

Magenta

Pyramidal neuron

Down with AD, enriched CA3

Midnight blue

Heat shock

Up with AD, down with PMI, batch, Brain Bank

Pink

Many mixed categories

---

Purple

Choroid plexus, extracellular signaling

---

Red

Oligodendrocyte, ribosome

Up with age

Salmon

Glia?

Up with AD

Tan

Neuron?

Down with age

Turquoise

Signal transduction

---

Yellow

Transcription, M9h

Up with AD duration, up with AD

  1. For each module, summary characterizations and trait associations are presented (as described in the text). Module characterizations in bold were confirmed in [46]. Trait associations in normal font were found in this study only, those in italics were found in previous studies only, and those in bold were found in both previous studies as well as this study.