From: Genes and pathways underlying regional and cell type changes in Alzheimer's disease
Module | Characterization | Trait association |
---|---|---|
Black | Astrocyte | Up with AD |
Blue | Mitochondria, neuron | Down with AD |
Brown | Pyramidal neuron | Down with AD duration, down with AD, enriched CA3 |
Cyan | Glutatmatergic synapse, neuron | Down with AD, down with age, enriched in CA3 |
Green | Astrocyte (and other glia), cell death? | Up with AD |
Green-yellow | Ribosome, oligodendrocyte | --- |
Grey60 | Microglia (M8)? | Up with AD |
Light cyan | Astrocyte | Enriched in CA1 |
Light green | Microglia (M10) | Enriched in CA1, up with NFTs in CT, up with AD |
Light yellow | Pval+ interneuron | Down with AD, enriched in CA1 |
Magenta | Pyramidal neuron | Down with AD, enriched CA3 |
Midnight blue | Heat shock | Up with AD, down with PMI, batch, Brain Bank |
Pink | Many mixed categories | --- |
Purple | Choroid plexus, extracellular signaling | --- |
Red | Oligodendrocyte, ribosome | Up with age |
Salmon | Glia? | Up with AD |
Tan | Neuron? | Down with age |
Turquoise | Signal transduction | --- |
Yellow | Transcription, M9h | Up with AD duration, up with AD |