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Table 3 Examples of gene expression studies of osteoporosis

From: Genome-wide approaches for identifying genetic risk factors for osteoporosis

Subjects and samples

Treatment

Differentially expressed genes

Important regulated genesa

Refs

Human osteoblasts isolated from trabecular bone tissue of femoral neck and proximal femur

Comparing the gene expression profiles of osteoblasts from osteoporotic versus non-osteoporotic bone tissues

1,606

Upregulated: IBSP, CXCL2; downregulated: PTN, COL15A1

[62]

Human MSCs

Oleanolic acid

256

Genes involved in osteoblastic differentiation

[69]

 

Ex vivo long-term cultivation

 

ID4, CRYAB, SORT1, TGF-β2, and BMPs

[64]

 

Cell culture

 

NDN, EPHA5, NOV, RUNX2

[65]

Human monocytes of low BMD subjects

Isolation from human blood

13

STAT1

[60]

Differentiation and proliferation of mouse osteoblast cells

High cholesterol

992 upregulated, 2,290 downregulated

Upregulated: TGF-β, BMP2, CBFA1, and proteins involved in Wnt signaling pathways; downregulated: IL-6 and AGER

[61]

Bone resorption and formation of male mice in high-fat diet

Antioxidant lipoic acid

17 upregulated, 19 downregulated

Upregulated: COL1A1, ALP1, IGF-1, and IL12; downregulated: MMP9, CTSK, P53, TGFBR1, and IL17a

[66]

Both pairs of femora and tibiae of Sprague-Dawley female rats

Three different PTH peptides, PTH(1-34), (1-31), and (3-34)

 

Slpi, tfpi2, socs3, gro1, RANKL, phex, Gprc5c, and CXCR4

[70]

  1. aFor gene abbreviations and explanations of pathways, see Table 5.