From: Protein-protein interaction networks: probing disease mechanisms using model systems
Model system | Disease | Approach | Reference(s) |
---|---|---|---|
Microbes | HIV infection | AP-MS, co-IP-MS identification of HIV-host PPIs | |
 | Viral infection | AP-MS identification of virus-host PPIs | [39] |
 | Measles | AP-MS identification of virus-host PPIs | [40] |
 | Hepatitis C | AP-MS identification of virus-host PPIs | [41] |
 | Japanese encephalitis | AP-MS identification of virus-host PPIs | [42] |
 | Lyme disease | Biochemical fractionation followed by native gel MS identification of protein complexes in outer membrane of Borrelia burgdorferi | [45] |
 | Chlamydia infection | Shotgun proteomic identification of Chlamydia trachomatis outer membrane protein complexes | [46] |
 | Bacterial meningitis | Two-dimensional native gel MS identification of outer membrane protein complexes in Neisseria meningitides | [47] |
 | MRSA infection | AP-MS identification of Staphylococcus aureus protein complexes | [48] |
 | Pneumonia | AP-MS of protein complexes in Mycoplasma pneumoniae | [49] |
Mouse | Multiple sclerosis | AP-MS identification of LRP-1-interacting proteins | [56] |
 | Huntington's disease | AP-MS identification of huntingtin-interacting proteins | |
 | Bovine spongiform encephalopathy | AP-MS identification of prion protein interactors | [60] |
 | Schizophrenia | AP-MS identification of DLG4 protein interactors | [59] |
Human | Breast cancer | AP-MS identification of SCRIB and ER alpha-interacting proteins | [71] |
 | Leber congenital amaurosis | AP-MS identification of proteins interacting with mutant lebercilin | [72] |
 | Muscular dystrophy | Co-IP MS identification of dystrophyin-interacting proteins | [73] |
 | Lung cancer | AP-MS identification of EGFR-associated proteins | [75] |
 | Melanoma | AP-MS identification of HIF2-interacting proteins | [76] |