Figure 1From: Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1Hepatic expression of OATP1B1, OATP1B3 and OATP2B1 varies between individuals, but is coordinately regulated within one individual. (a) Representative immunoblot of liver membrane fractions (20 μg) quantified relative to a standard liver sample. (b-d) Correlation analyses of OATP protein and SLCO mRNA levels in human liver samples. (e, f) Correlation analyses of all three OATPs showed a coordinated expression of SLCO1B1, SLCO1B3, and SLCO2B1 mRNA and OATP1B1, OATP1B3, and OATP2B1 protein levels in the non-cholestatic liver sample set. rS, Spearman rank-order correlation coefficient.Back to article page