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Table 4 Summary of partial least squares regressions between urinary metabolic profiles and HOMA-IR.

From: Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling

Day

P

Metabolite name

HMDB ID

R

P

Day 1

0.015

L-proline

HMDB00162

+

0.002

  

L-alanine

HMDB00161

+

0.003

  

L-glutamic acid

HMDB00148

+

0.006

  

L-valine

HMDB00883

+

0.006

  

L-leucine

HMDB00687

+

0.011

  

L-serine

HMDB00187

+

0.017

  

Propionylcarnitine

HMDB00824

+

0.022

  

L-phenylalanine

HMDB00159

+

0.024

  

L-isoleucine

HMDB00172

+

0.029

  

L-methionine

HMDB00696

+

0.032

  

L-acetylcarnitine

HMDB00201

+

0.044

  

L-histidine

HMDB00177

+

0.045

Day 15

0.004

Tartaric acid

HMDB00956

-

0.013

  

Androsterone sulfate

HMDB02759

-

0.013

  

Proline betaine

HMDB04827

-

0.014

  

N-methylnicotinamide

HMDB03152

-

0.016

  

Pimelic acid

HMDB00857

-

0.025

  

L-alanine

HMDB00161

+

0.027

  

N-acetylvaline

HMDB11757

+

0.028

  

Taurine

HMDB00251

-

0.037

  

Isocitric acid

HMDB00193

-

0.05

  1. The sign of the correlation coefficients to the regression axe (R) and P-values are displayed only for metabolites significantly associated with HOMA-IR. HMDB, Human Metabolome Database, HOMA-IR, homeostatic model assessment of insulin resistance.