From: Pharmacogenomics of chemotherapeutic susceptibility and toxicity
Gene | Drug(s) | Chemotherapeutic response versus toxicity | Reference(s) |
---|---|---|---|
In tumor genome | Â | Â | Â |
BRAF | Vemurafenib | Response | [82] |
KIT | Imatinib | Response | [83] |
EGFR | Cetuximab, erlotinib, Gefitinib, panitumumab | Response | |
KRAS | Cetuximab, panitumumab | Response | |
In germline genome | Â | Â | Â |
G6PD | Rasburicase | Toxicity | [89] |
TPMT | Cisplatin, 6-MP, 6-TG | Toxicity | |
UGT1A1 | Irinotecan, nilotinib | Toxicity | |
DPYD | Capecitabine | Toxicity | [30] |