Figure 1
From: Pharmacogenomics of chemotherapeutic susceptibility and toxicity
Integration of LCL datasets allows for comprehensive investigation of genotype-phenotype relationships. Genotype information can be found in the International HapMap Project or 1000 Genomes Project databases. Publicly available cytosine modification and microRNA data can be included to identify SNPs associated with these epigenetic factors. Genetics and epigenetics can both influence gene transcriptional activity, which may ultimately lead to variation in pharmacological phenotypes.