Table 4 Candidate gene studies of antidepressant treatment response undertaken in large cohorts
Gene | Study | Drug | Sample size | Significant association |
|---|---|---|---|---|
SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) | STAR*D [1] | Citalopram | 1,775 | No (but see [2]) |
| Â | GENDEP [3] | Escitalopram | 450 | 5HTTLPR, rs2020933 |
| Â | Â | Nortriptyline | 345 | No |
| Â | GenPod [4] | Citalopram/reboxetine | 520 | No |
HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G-protein-coupled) | STAR*D [5] | Citalopram | 1,297 | rs7997012 (also see [6]) |
| Â | MARS [7] | Various | 451 (plus replication sample) | rs7997012: reverse allelic association to [5] |
| Â | GENDEP [3] | Escitalopram | 422 | rs931623, rs2224721 |
FKBP5 (FK506 binding protein 5) | STAR*D [8] | Citalopram | 1,809 | rs4713916 |
| Â | MARS [9] | Various | 294 (plus replication sample) | rs1360780, rs3800373, rs4713916 |
| Â | GENDEP [3] | Escitalopram or nortriptyline | 733 | No |
GRIK4 (glutamate receptor, ionotropic, kainate 4) | STAR*D [6] | Citalopram | 1,816 | rs1954787 |
| Â | MARS [10] | Various | 300 | No |