In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

Alfirevic, Ana; Gonzalez-Galarza, Faviel; Bell, Catherine; Martinsson, Klara; Platt, Vivien; Bretland, Giovanna; Evely, Jane; Lichtenfels, Maike; Cederbrant, Karin; French, Neil; Naisbitt, Dean; Park, B Kevin; Jones, Andrew R; Pirmohamed, Munir

doi:10.1186/gm350

Table 3 Allele and genotype frequencies in Caucasians from the HLA-typed archive described in the present study (North West England, n = 298)

From: In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

HLA-A			HLA-B			HLA-C			HLA-DRB1			HLA-DQB1
Allele	AF	GF (%)	Allele	AF	GF (%)	Allele	AF	GF (%)	Allele	AF	GF (%)	Allele	AF	GF (%)
A*01:01g	0.208	38.6	B*07:02g	0.153	27.5	C*01:02g	0.040	8.1	DRB1*01:01:01	0.086	16.1	*DQB102:01g**	0.273	48.0
A*01:06	0.002	0.3	B*07:05g	0.003	0.7	C*02:02:02	0.035	7.0	DRB1*01:02:01	0.007	1.3	DQB1*03:01g	0.154	28.2
A*02:01g	0.289	50.7	*B08:01g**	0.154	29.9	C*03:02	0.003	0.7	DRB1*01:03	0.018	3.7	DQB1*03:02:01	0.116	21.5
A*02:05g	0.010	2.0	B*13:02	0.007	1.3	C*03:03g	0.064	12.8	DRB1*03:01:01	0.154	28.9	*DQB103:03:02**	0.049	9.7
A*02:20:01	0.002	0.3	B*14:01	0.010	2.0	C*03:04	0.076	14.4	DRB1*04:01:01	0.116	21.5	DQB1*03:04	0.003	0.7
A*02:24	0.002	0.3	B*14:02:01	0.025	5.0	C*04:01g	0.062	11.4	DRB1*04:02	0.008	1.7	DQB1*04:02	0.015	3.0
A*03:01g	0.138	25.5	B*15:01g	0.059	11.7	C*05:01g	0.102	19.5	DRB1*04:03:01	0.008	1.7	DQB1*05:01:01	0.112	20.5
A*03:02	0.003	0.7	B*15:03g	0.003	0.7	C*06:02	0.086	16.4	DRB1*04:04	0.047	9.4	DQB1*05:02:01	0.005	1.0
A*11:01g	0.070	13.1	B*15:07	0.002	0.3	C*07:01g	0.190	35.2	DRB1*04:05:01	0.002	0.3	DQB1*05:03:01	0.017	3.4
A*23:01g	0.018	3.7	B*15:16	0.002	0.3	C*07:02g	0.156	27.9	DRB1*04:06	0.002	0.3	DQB1*05:04	0.002	0.3
A*24:02g	0.069	13.8	B*15:17	0.003	0.7	C*07:04g	0.008	1.7	DRB1*04:07:01	0.012	2.3	DQB1*06:01	0.010	2.0
A*24:03g	0.002	0.3	B*15:18	0.003	0.7	C*08:02	0.032	6.4	DRB1*04:08	0.005	1.0	*DQB106:02:01**	0.149	27.5
A*25:01g	0.022	4.4	B*18:01g	0.045	9.1	C*08:03:01	0.002	0.3	*DRB107**:01:01	0.156	28.9	DQB1*06:03:01	0.055	11.1
A*26:01g	0.020	4.0	B*27:05g	0.042	8.1	C*12:02	0.010	2.0	DRB1*08:01	0.013	2.7	*DQB106:04g**	0.022	4.4
A*29:01g	0.003	0.7	B*35:01g	0.032	6.4	C*12:03	0.047	9.4	DRB1*08:03:02	0.003	0.7	DQB1*06:09	0.017	3.0
A*29:02:01	0.032	6.4	B*35:02:01	0.003	0.7	C*14:02:01	0.010	2.0	DRB1*09:01:02	0.012	2.3		1.000
A*30:01g	0.007	1.3	B*35:03g	0.012	2.3	C*15:02g	0.023	4.7	DRB1*10:01:01	0.007	1.3
A*30:02	0.010	2.0	B*35:08:01	0.003	0.7	C*15:05	0.003	0.7	DRB1*11:01	0.034	6.4
A*31:01g	0.029	5.7	B*37:01:01	0.018	3.7	C*16:01:01	0.045	9.1	DRB1*11:02:01	0.002	0.3
A*32:01	0.027	5.4	B*38:01:01	0.010	2.0	C*16:02	0.003	0.7	DRB1*11:03	0.008	1.7
A*33:01	0.003	0.7	B*39:01g	0.007	1.3	C*17:01g	0.002	0.3	DRB1*11:04:01	0.008	1.7
*A33:03g**	0.003	0.7	B*39:06:02	0.002	0.3		1.000		DRB1*12:01g	0.010	2.0
A*66:01g	0.005	1.0	B*40:01g	0.060	11.4				DRB1*13:01:01	0.045	9.1
A*68:01g	0.018	3.7	B*40:02g	0.005	1.0				*DRB113:02:01**	0.039	7.0
A*68:02	0.007	1.3	B*41:01	0.002	0.3				DRB1*13:03:01	0.003	0.7
A*74:03	0.002	0.3	B*41:02:01	0.002	0.3				DRB1*13:05:01	0.003	0.7
			B*44:02g	0.101	19.1				DRB1*14:01g	0.017	3.4
			B*44:03	0.055	11.1				*DRB115**:01	0.159	28.9
			B*44:04	0.002	0.3				DRB1*15:02:01	0.010	2.0
			B*44:05	0.002	0.3				DRB1*16:01:01	0.002	0.3
			B*45:01g	0.005	1.0				DRB1*16:02:01	0.003	0.7
			B*47:01	0.005	1.0					1.000
			B*48:01g	0.002	0.3
			B*49:01	0.007	1.3
			B*50:01	0.017	3.4
			B*50:02	0.002	0.3
			B*51:01g	0.047	9.4
			B*52:01g	0.010	2.0
			B*53:01:01	0.005	1.0
			B*55:01	0.023	4.7
			B*56:01g	0.008	1.7
			*B57**:01:01	0.037	7.0

AF, allele frequency; GF, genotype frequency (percentage of individuals carrying the allele). Alleles associated with DILI are shown in bold. Generic codes for ambiguities are denoted with the suffix 'g' (Table S5 in Additional file 1).

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