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Table 3 Number of metabolites in the major biochemical classes detected in various human tissues

From: Cancer detection and biopsy classification using concurrent histopathological and metabolomic analysis of core biopsies

 

Tissue type

Biochemical super pathway

Adrenal gland (1)

Colon (4)

Lung (1)

Muscle (4)

Pancreas (3)

Small intestine (4)

Spleen (1)

Stomach (4)

Prostate (8)

Kidney (3)

Amino acid

69

80

71

77

71

74

62

80

70

81

Peptide

35

40

36

37

42

43

38

42

6

24

Carbohydrate

25

26

27

28

26

25

23

27

21

19

Energy

8

8

8

8

8

8

8

8

10

7

Lipid

102

129

112

122

117

124

90

125

101

107

Nucleotide

23

28

24

25

26

26

24

27

20

22

Cofactors and vitamins

8

12

9

10

8

9

7

10

13

13

Xenobiotics

13

17

12

15

13

15

10

15

17

20

Total

283

340

299

322

311

324

262

334

260

293

  1. Adrenal gland, colon, lung, muscle, pancreas, small intestine, spleen, and stomach samples were collected from beating heart donors just prior to the withdrawal of support, placed immediately in 80% methanol and incubated for 24 to 72 h at room temperature. Prostate refers to benign human tissue biopsy samples collected post-prostatectomy from regions of the prostate that did not contain cancer and processed in 80% methanol as described. Kidney refers to the fresh frozen normal human kidney tissue analyzed in the incubation time course experiment reported in Table 1. The number of metabolites detected in each biochemical class is indicated. The number of samples analyzed for each tissue type is indicated in parentheses.