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Table 1 Levels of unconjugated endogenous estrogens (picograms) found in NCI-60 cell lines

From: Concentration of endogenous estrogens and estrogen metabolites in the NCI-60 human tumor cell lines

Cancer

Cell Line

E3

16αOHE1

16-epiE3

2MeOE1

2MeOE2

E1

E2

2OHE1

2OHE2

Total

Breast

T-47D

0.80

0.03

0.33

2.70

0.54

3.65

87.37

NF

7.30

102.72

  

(0.07)

(0.00)

(0.04)

(0.34)

(0.10)

(0.06)

(2.69)

NF

(1.22)

(3.18)

Breast

Hs-578T

0.43

0.03

0.22

0.62

0.94

8.13

74.11

NF

5.86

90.35

  

(0.06)

(0.00)

(0.05)

(0.07)

(0.17)

(0.98)

(9.94)

NF

(0.83)

(11.95)

Breast

BT-549

0.58

0.02

0.06

0.65

0.45

8.45

58.97

NF

6.03

75.22

  

(0.10)

(0.00)

(0.03)

(0.10)

(0.02)

(1.20)

(11.51)

NF

(1.26)

(14.15)

Breast

MDA-MB-231

0.90

0.02

0.57

1.78

0.35

6.30

36.73

NF

2.55

49.21

  

(0.07)

(0.00)

(0.05)

(0.24)

(0.05)

(0.37)

(2.41)

NF

(0.33)

(2.71)

Breast

MCF-7

0.40

0.04

0.28

2.12

5.38

7.70

80.75

NF

1.76

98.42

  

(0.03)

(0.00)

(0.06)

(0.23)

(0.47)

(0.71)

(14.44)

NF

(0.06)

(13.04)

CNS

SF-295

0.24

0.04

0.12

0.93

0.81

6.79

41.51

NF

7.01

57.44

  

(0.03)

(0.00)

(0.01)

(0.07)

(0.12)

(0.93)

(2.57)

NF

(1.03)

(3.25)

CNS

SF-539

0.82

0.11

NF

1.73

1.22

26.24

175.50

NF

27.11

232.78

  

(0.10)

(0.02)

NF

(0.13)

(0.08)

(2.01)

(13.14)

NF

(2.78)

(14.43)

CNS

SF-268

0.35

0.04

0.31

0.43

0.26

2.69

24.68

NF

7.67

36.42

  

(0.01)

(0.00)

(0.03)

(0.05)

(0.01)

(0.10)

(1.33)

NF

(0.96)

(2.21)

CNS

U251

0.35

0.29

0.21

1.19

0.31

4.54

41.06

NF

12.61

60.55

  

(0.04)

(0.03)

(0.02)

(0.11)

(0.04)

(0.21)

(4.27)

NF

(1.22)

(5.01)

CNS

SNB-19

0.31

0.02

0.08

1.27

0.55

5.09

29.34

NF

3.63

40.29

  

(0.05)

(0.00)

(0.01)

(0.14)

(0.09)

(0.64)

(2.31)

NF

(0.25)

(3.45)

CNS

SNB-75

0.30

0.04

0.10

1.46

0.56

13.15

94.94

NF

2.23

112.79

  

(0.04)

(0.00)

(0.01)

(0.23)

(0.03)

(0.57)

(1.97)

NF

(0.24)

(1.80)

Colon

SW-620

0.75

0.08

0.28

1.70

1.39

0.44

1.31

NF

2.68

8.63

  

(0.11)

(0.01)

(0.05)

(0.14)

(0.23)

(0.05)

(0.09)

NF

(0.31)

(0.61)

Colon

HCT-116

0.12

0.02

0.27

1.40

0.80

0.45

2.17

NF

0.33

5.58

  

(0.02)

(0.00)

(0.04)

(0.06)

(0.08)

(0.04)

(0.13)

NF

(0.03)

(0.11)

Colon

COLO-205

0.33

0.07

0.19

0.57

0.76

1.12

50.44

NF

15.20

68.69

  

(0.02)

(0.01)

(0.02)

(0.07)

(0.07)

(0.08)

(4.57)

NF

(0.77)

(5.22)

Colon

KM12

0.55

0.04

0.31

1.09

0.44

0.14

1.77

NF

0.73

5.06

  

(0.06)

(0.00)

(0.04)

(0.10)

(0.09)

(0.01)

(0.12)

NF

(0.13)

(0.49)

Colon

HT29

0.51

0.03

0.51

1.12

0.28

1.90

30.71

NF

0.51

35.56

  

(0.01)

(0.00)

(0.06)

(0.12)

(0.03)

(0.10)

(1.12)

NF

(0.05)

(0.90)

Colon

HCT-15

28.10

0.40

1.08

0.87

0.29

0.88

12.25

NF

3.75

47.62

  

(1.54)

(0.06)

(0.04)

(0.09)

(0.03)

(0.10)

(1.22)

NF

(0.36)

(3.05)

Colon

HCC-2998

0.88

0.10

0.45

3.10

0.92

17.10

209.34

NF

4.29

236.18

  

(0.05)

(0.01)

(0.07)

(0.05)

(0.17)

(0.08)

(13.95)

NF

(0.14)

(14.05)

Leukemia

HL-60

3.89

0.03

0.29

1.58

3.15

18.78

36.61

NF

16.50

80.83

  

(0.02)

(0.00)

(0.01)

(0.11)

(0.10)

(2.39)

(2.70)

NF

(2.81)

(2.39)

Leukemia

CCRF-CEM

0.41

0.04

0.06

0.66

1.33

1.18

3.48

NF

1.16

8.31

  

(0.07)

(0.00)

(0.02)

(0.04)

(0.10)

(0.12)

(0.50)

NF

(0.10)

(0.91)

Leukemia

K562

0.42

0.02

0.21

0.57

2.23

0.56

13.88

NF

1.16

33.14

  

(0.07)

(0.00)

(0.04)

(0.06)

(0.07)

(0.06)

(1.75)

NF

(0.11)

(1.24)

Leukemia

MOLT-4

0.30

0.08

0.13

0.55

0.77

2.04

7.77

NF

0.75

12.37

  

(0.04)

(0.01)

(0.01)

(0.04)

(0.07)

(0.37)

(1.14)

NF

(0.09)

(1.53)

Leukemia

RMPI-8226

0.93

0.11

0.59

2.04

3.60

182.06

753.45

NF

2.93

945.71

  

(0.07)

(0.02)

(0.11)

(0.30)

(0.16)

(5.19)

(48.20)

NF

(0.22)

(52.18)

Leukemia

SR

4.67

0.06

0.80

3.24

1.45

6.67

26.39

NF

1.22

44.51

  

(0.53)

(0.01)

(0.15)

(0.51)

(0.22)

(0.47)

(1.38)

NF

(0.19)

(2.00)

Melanoma

MDA-MB-435

0.37

0.22

0.09

0.61

3.65

1.77

14.24

NF

2.82

23.77

  

(0.03)

(0.04)

(0.02)

(0.11)

(0.76)

(0.18)

(0.91)

NF

(0.32)

(1.05)

Melanoma

SK-MEL-28

0.82

0.05

0.27

3.83

5.41

21.50

146.59

NF

27.77

206.24

  

(0.03)

(0.01)

(0.02)

(0.33)

(0.99)

(2.12)

(15.34)

NF

(2.17)

(16.78)

Melanoma

UACC-257

1.20

0.36

0.37

0.74

7.00

36.36

130.70

NF

2.50

179.23

  

(0.23)

(0.07)

(0.05)

(0.10)

(0.78)

(2.41)

(4.37)

NF

(0.22)

(6.37)

Melanoma

LOX IMVI

0.93

0.07

0.44

1.33

1.01

0.35

12.10

NF

8.26

24.49

  

(0.11)

(0.01)

(0.07)

(0.06)

(0.07)

(0.02)

(0.55)

NF

(0.64)

(0.50)

Melanoma

UACC-62

0.20

0.30

0.06

1.41

1.47

17.49

98.71

NF

1.62

121.27

  

(0.03)

(0.04)

(0.01)

(0.06)

(0.25)

(0.21)

(4.61)

NF

(0.30)

(4.82)

Melanoma

SK-MEL-2

1.56

1.60

0.38

2.21

0.62

6.66

50.93

NF

2.90

66.86

  

(0.15)

(0.08)

(0.07)

(0.05)

(0.08)

(0.40)

(5.84)

NF

(0.33)

(6.40)

Melanoma

SK-MEL-5

0.38

0.38

0.13

14.84

0.52

11.64

72.02

NF

3.83

103.75

  

(0.03)

(0.05)

(0.02)

(0.47)

(0.08)

(0.31)

(4.06)

NF

(0.50)

(5.25)

Melanoma

MALME-3M

0.36

0.06

0.32

3.88

0.45

1.26

94.27

NF

1.30

101.90

  

(0.03)

(0.01)

(0.05)

(0.26)

(0.06)

(0.05)

(0.88)

NF

(0.13)

(1.13)

Melanoma

M14

1.33

0.05

0.18

1.24

0.69

1.21

13.95

NF

1.90

20.55

  

(0.06)

(0.00)

(0.02)

(0.11)

(0.11)

(0.09)

(0.50)

NF

(0.28)

(0.91)

NSCL

A549

0.56

0.04

0.54

1.04

1.18

2.95

17.01

NF

2.19

25.51

  

(0.06)

(0.00)

(0.05)

(0.05)

(0.07)

(0.27)

(0.86)

NF

(0.24)

(1.18)

NSCL

EKVX

1.70

0.31

0.92

1.10

7.16

15.16

125.95

NF

4.53

156.83

  

(0.06)

(0.05)

(0.01)

(0.12)

(0.72)

(1.13)

(13.92)

NF

(0.47)

(12.21)

NSCL

HOP-62

1.48

0.08

0.78

2.37

4.70

6.19

25.45

NF

13.29

54.33

  

(0.24)

(0.01)

(0.14)

(0.40)

(0.44)

(1.18)

(1.85)

NF

(1.56)

(5.04)

NSCL

NCI-H23

1.08

0.29

0.39

6.10

0.92

8.03

90.47

NF

15.79

123.07

  

(0.05)

(0.04)

(0.08)

(0.43)

(0.05)

(0.64)

(2.81)

NF

(2.87)

(3.46)

NSCL

NCI-H460

0.18

0.05

0.15

1.36

1.15

4.03

59.76

27.89

2.21

96.78

  

(0.01)

(0.01)

(0.00)

(0.23)

(0.04)

(0.06)

(3.33)

(0.32)

(0.12)

(3.69)

NSCL

NCI-H226

0.29

0.07

0.13

0.50

0.61

25.40

181.13

NF

21.63

229.75

  

(0.02)

(0.01)

(0.01)

(0.02)

(0.07)

(1.05)

(7.48)

NF

(0.69)

(8.87)

NSCL

HOP-92

0.33

0.03

0.43

0.55

0.24

4.87

34.58

NF

2.20

43.24

  

(0.01)

(0.00)

(0.08)

(0.03)

(0.04)

(0.28)

(1.51)

NF

(0.24)

(1.43)

NSCL

NCI-H522

0.18

0.03

0.06

1.38

0.31

4.25

32.36

NF

1.55

40.12

  

(0.02)

(0.00)

(0.01)

(0.08)

(0.04)

(0.36)

(2.39)

NF

(0.31)

(2.58)

NSCL

NCI-H322M

0.19

0.04

0.13

0.80

0.45

0.72

7.01

NF

1.29

10.62

  

(0.02)

(0.00)

(0.01)

(0.06)

(0.04)

(0.08)

(0.27)

NF

(0.12)

(0.13)

Ovarian

OVCAR-3

0.50

0.07

0.34

0.97

3.70

5.37

26.60

NF

5.47

43.02

  

(0.05)

(0.01)

(0.04)

(0.09)

(0.54)

(0.73)

(1.63)

NF

(0.81)

(3.21)

Ovarian

OVCAR-5

0.16

0.03

0.13

1.26

0.33

12.85

107.47

NF

1.57

123.79

  

(0.00)

(0.00)

(0.02)

(0.17)

(0.05)

(0.33)

(5.55)

NF

(0.14)

(5.89)

Ovarian

IGR-OV1

0.15

0.04

0.11

0.73

2.54

4.00

29.72

NF

0.66

37.94

  

(0.01)

(0.00)

(0.00)

(0.01)

(0.36)

(0.15)

(0.70)

NF

(0.06)

(1.10)

Ovarian

NCI/ADR-RES

1.33

0.15

0.44

2.54

2.92

10.46

75.10

NF

4.61

97.56

  

(0.08)

(0.02)

(0.04)

(0.28)

(0.14)

(0.31)

(0.47)

NF

(0.28)

(0.06)

Ovarian

SK-OV-3

1.78

0.13

0.39

0.73

0.55

12.26

132.33

NF

4.18

152.36

  

(0.23)

(0.02)

(0.03)

(0.09)

(0.10)

(0.25)

(9.43)

NF

(0.63)

(9.94)

Ovarian

OVCAR-8

0.44

0.13

0.15

2.10

0.35

5.12

38.83

NF

3.61

50.73

  

(0.02)

(0.03)

(0.03)

(0.17)

(0.06)

(0.22)

(1.01)

NF

(0.58)

(1.56)

Ovarian

OVCAR-4

0.43

0.06

0.31

3.90

0.43

19.79

139.32

NF

4.69

168.93

  

(0.02)

(0.01)

(0.02)

(0.06)

(0.07)

(1.06)

(2.84)

NF

(0.46)

(2.82)

Prostate

PC-3

0.15

0.03

0.20

1.05

2.33

7.63

41.94

NF

0.63

53.96

  

(0.02)

(0.00)

(0.03)

(0.05)

(0.14)

(0.56)

(2.30)

NF

(0.07)

(2.90)

Prostate

DU145

0.55

0.04

0.42

2.22

0.71

4.94

27.78

NF

2.55

39.22

  

(0.05)

(0.00)

(0.05)

(0.16)

(0.10)

(0.29)

(1.02)

NF

(0.23)

(1.06)

Renal

UO-31

0.30

0.13

0.33

1.36

1.66

5.05

22.94

NF

2.45

34.22

  

(0.03

(0.02

(0.02

(0.26

(0.26

(0.60

(1.18

NF

(0.15

(0.92

Renal

786-0

0.15

0.02

0.11

0.58

0.16

2.11

23.40

NF

1.54

28.07

  

(0.02)

(0.00)

(0.01)

(0.05)

(0.02)

(0.16)

(0.14)

NF

(0.19)

(0.17)

Renal

SN12C

0.14

0.05

0.27

6.47

1.92

4.02

25.50

NF

0.89

39.25

  

(0.01)

(0.01)

(0.02)

(0.29)

(0.17)

(0.07)

(0.97)

NF

(0.05)

(0.96)

Renal

CAKI-1

0.54

0.16

0.13

4.76

0.49

7.57

81.60

NF

6.52

101.77

  

(0.05)

(0.03)

(0.03)

(0.42)

(0.07)

(0.61)

(1.42)

NF

(0.79)

(2.29)

Renal

RXF-393

0.27

0.03

0.09

0.47

0.44

0.34

14.48

NF

1.41

17.54

  

(0.04)

(0.00)

(0.02)

(0.09)

(0.04)

(0.04)

(0.39)

NF

(0.13)

(0.38)

Renal

TK-10

0.65

0.25

0.42

2.54

0.58

7.87

37.29

NF

6.25

55.86

  

(0.06)

(0.04)

(0.02)

(0.24)

(0.06)

(0.22)

(3.96)

NF

(0.60)

(4.27)

Renal

A498

0.53

0.02

0.16

0.29

0.50

3.05

37.53

NF

2.58

44.65

  

(0.04)

(0.00)

(0.00)

(0.03)

(0.07)

(0.29)

(1.09)

NF

(0.37)

(1.45)

Renal

ACHN

0.43

0.08

0.19

1.25

0.39

6.17

39.27

NF

3.40

51.17

  

(0.06)

(0.01)

(0.02)

(0.16)

(0.06)

(0.74)

(1.96)

NF

(0.28)

(2.51)

  1. Data are expressed as mean (standard deviation) of three replicated analyses of 106 cells. E3, estriol; 16αOHE1, 16α-hydroxyestrone; 16-epiE3, 16-epiestriol; 2MeOE1, 2-methoxyestrone; 2MeOE2, 2-methoxyestradiol; E1, estrone; E2, 17β-estradiol; 2OHE1, 2-hydroxyestrone; 2OHE2, 2-hydroxyestradiol; CNS, central nervous system; NF, not found; NSCLC, non-small cell lung carcinoma.