From: Concentration of endogenous estrogens and estrogen metabolites in the NCI-60 human tumor cell lines
Cancer | Cell Line | E3 | 16αOHE1 | 16-epiE3 | 2MeOE1 | 2MeOE2 | E1 | E2 | 2OHE1 | 2OHE2 | Total |
---|---|---|---|---|---|---|---|---|---|---|---|
Breast | T-47D | 0.80 | 0.03 | 0.33 | 2.70 | 0.54 | 3.65 | 87.37 | NF | 7.30 | 102.72 |
(0.07) | (0.00) | (0.04) | (0.34) | (0.10) | (0.06) | (2.69) | NF | (1.22) | (3.18) | ||
Breast | Hs-578T | 0.43 | 0.03 | 0.22 | 0.62 | 0.94 | 8.13 | 74.11 | NF | 5.86 | 90.35 |
(0.06) | (0.00) | (0.05) | (0.07) | (0.17) | (0.98) | (9.94) | NF | (0.83) | (11.95) | ||
Breast | BT-549 | 0.58 | 0.02 | 0.06 | 0.65 | 0.45 | 8.45 | 58.97 | NF | 6.03 | 75.22 |
(0.10) | (0.00) | (0.03) | (0.10) | (0.02) | (1.20) | (11.51) | NF | (1.26) | (14.15) | ||
Breast | MDA-MB-231 | 0.90 | 0.02 | 0.57 | 1.78 | 0.35 | 6.30 | 36.73 | NF | 2.55 | 49.21 |
(0.07) | (0.00) | (0.05) | (0.24) | (0.05) | (0.37) | (2.41) | NF | (0.33) | (2.71) | ||
Breast | MCF-7 | 0.40 | 0.04 | 0.28 | 2.12 | 5.38 | 7.70 | 80.75 | NF | 1.76 | 98.42 |
(0.03) | (0.00) | (0.06) | (0.23) | (0.47) | (0.71) | (14.44) | NF | (0.06) | (13.04) | ||
CNS | SF-295 | 0.24 | 0.04 | 0.12 | 0.93 | 0.81 | 6.79 | 41.51 | NF | 7.01 | 57.44 |
(0.03) | (0.00) | (0.01) | (0.07) | (0.12) | (0.93) | (2.57) | NF | (1.03) | (3.25) | ||
CNS | SF-539 | 0.82 | 0.11 | NF | 1.73 | 1.22 | 26.24 | 175.50 | NF | 27.11 | 232.78 |
(0.10) | (0.02) | NF | (0.13) | (0.08) | (2.01) | (13.14) | NF | (2.78) | (14.43) | ||
CNS | SF-268 | 0.35 | 0.04 | 0.31 | 0.43 | 0.26 | 2.69 | 24.68 | NF | 7.67 | 36.42 |
(0.01) | (0.00) | (0.03) | (0.05) | (0.01) | (0.10) | (1.33) | NF | (0.96) | (2.21) | ||
CNS | U251 | 0.35 | 0.29 | 0.21 | 1.19 | 0.31 | 4.54 | 41.06 | NF | 12.61 | 60.55 |
(0.04) | (0.03) | (0.02) | (0.11) | (0.04) | (0.21) | (4.27) | NF | (1.22) | (5.01) | ||
CNS | SNB-19 | 0.31 | 0.02 | 0.08 | 1.27 | 0.55 | 5.09 | 29.34 | NF | 3.63 | 40.29 |
(0.05) | (0.00) | (0.01) | (0.14) | (0.09) | (0.64) | (2.31) | NF | (0.25) | (3.45) | ||
CNS | SNB-75 | 0.30 | 0.04 | 0.10 | 1.46 | 0.56 | 13.15 | 94.94 | NF | 2.23 | 112.79 |
(0.04) | (0.00) | (0.01) | (0.23) | (0.03) | (0.57) | (1.97) | NF | (0.24) | (1.80) | ||
Colon | SW-620 | 0.75 | 0.08 | 0.28 | 1.70 | 1.39 | 0.44 | 1.31 | NF | 2.68 | 8.63 |
(0.11) | (0.01) | (0.05) | (0.14) | (0.23) | (0.05) | (0.09) | NF | (0.31) | (0.61) | ||
Colon | HCT-116 | 0.12 | 0.02 | 0.27 | 1.40 | 0.80 | 0.45 | 2.17 | NF | 0.33 | 5.58 |
(0.02) | (0.00) | (0.04) | (0.06) | (0.08) | (0.04) | (0.13) | NF | (0.03) | (0.11) | ||
Colon | COLO-205 | 0.33 | 0.07 | 0.19 | 0.57 | 0.76 | 1.12 | 50.44 | NF | 15.20 | 68.69 |
(0.02) | (0.01) | (0.02) | (0.07) | (0.07) | (0.08) | (4.57) | NF | (0.77) | (5.22) | ||
Colon | KM12 | 0.55 | 0.04 | 0.31 | 1.09 | 0.44 | 0.14 | 1.77 | NF | 0.73 | 5.06 |
(0.06) | (0.00) | (0.04) | (0.10) | (0.09) | (0.01) | (0.12) | NF | (0.13) | (0.49) | ||
Colon | HT29 | 0.51 | 0.03 | 0.51 | 1.12 | 0.28 | 1.90 | 30.71 | NF | 0.51 | 35.56 |
(0.01) | (0.00) | (0.06) | (0.12) | (0.03) | (0.10) | (1.12) | NF | (0.05) | (0.90) | ||
Colon | HCT-15 | 28.10 | 0.40 | 1.08 | 0.87 | 0.29 | 0.88 | 12.25 | NF | 3.75 | 47.62 |
(1.54) | (0.06) | (0.04) | (0.09) | (0.03) | (0.10) | (1.22) | NF | (0.36) | (3.05) | ||
Colon | HCC-2998 | 0.88 | 0.10 | 0.45 | 3.10 | 0.92 | 17.10 | 209.34 | NF | 4.29 | 236.18 |
(0.05) | (0.01) | (0.07) | (0.05) | (0.17) | (0.08) | (13.95) | NF | (0.14) | (14.05) | ||
Leukemia | HL-60 | 3.89 | 0.03 | 0.29 | 1.58 | 3.15 | 18.78 | 36.61 | NF | 16.50 | 80.83 |
(0.02) | (0.00) | (0.01) | (0.11) | (0.10) | (2.39) | (2.70) | NF | (2.81) | (2.39) | ||
Leukemia | CCRF-CEM | 0.41 | 0.04 | 0.06 | 0.66 | 1.33 | 1.18 | 3.48 | NF | 1.16 | 8.31 |
(0.07) | (0.00) | (0.02) | (0.04) | (0.10) | (0.12) | (0.50) | NF | (0.10) | (0.91) | ||
Leukemia | K562 | 0.42 | 0.02 | 0.21 | 0.57 | 2.23 | 0.56 | 13.88 | NF | 1.16 | 33.14 |
(0.07) | (0.00) | (0.04) | (0.06) | (0.07) | (0.06) | (1.75) | NF | (0.11) | (1.24) | ||
Leukemia | MOLT-4 | 0.30 | 0.08 | 0.13 | 0.55 | 0.77 | 2.04 | 7.77 | NF | 0.75 | 12.37 |
(0.04) | (0.01) | (0.01) | (0.04) | (0.07) | (0.37) | (1.14) | NF | (0.09) | (1.53) | ||
Leukemia | RMPI-8226 | 0.93 | 0.11 | 0.59 | 2.04 | 3.60 | 182.06 | 753.45 | NF | 2.93 | 945.71 |
(0.07) | (0.02) | (0.11) | (0.30) | (0.16) | (5.19) | (48.20) | NF | (0.22) | (52.18) | ||
Leukemia | SR | 4.67 | 0.06 | 0.80 | 3.24 | 1.45 | 6.67 | 26.39 | NF | 1.22 | 44.51 |
(0.53) | (0.01) | (0.15) | (0.51) | (0.22) | (0.47) | (1.38) | NF | (0.19) | (2.00) | ||
Melanoma | MDA-MB-435 | 0.37 | 0.22 | 0.09 | 0.61 | 3.65 | 1.77 | 14.24 | NF | 2.82 | 23.77 |
(0.03) | (0.04) | (0.02) | (0.11) | (0.76) | (0.18) | (0.91) | NF | (0.32) | (1.05) | ||
Melanoma | SK-MEL-28 | 0.82 | 0.05 | 0.27 | 3.83 | 5.41 | 21.50 | 146.59 | NF | 27.77 | 206.24 |
(0.03) | (0.01) | (0.02) | (0.33) | (0.99) | (2.12) | (15.34) | NF | (2.17) | (16.78) | ||
Melanoma | UACC-257 | 1.20 | 0.36 | 0.37 | 0.74 | 7.00 | 36.36 | 130.70 | NF | 2.50 | 179.23 |
(0.23) | (0.07) | (0.05) | (0.10) | (0.78) | (2.41) | (4.37) | NF | (0.22) | (6.37) | ||
Melanoma | LOX IMVI | 0.93 | 0.07 | 0.44 | 1.33 | 1.01 | 0.35 | 12.10 | NF | 8.26 | 24.49 |
(0.11) | (0.01) | (0.07) | (0.06) | (0.07) | (0.02) | (0.55) | NF | (0.64) | (0.50) | ||
Melanoma | UACC-62 | 0.20 | 0.30 | 0.06 | 1.41 | 1.47 | 17.49 | 98.71 | NF | 1.62 | 121.27 |
(0.03) | (0.04) | (0.01) | (0.06) | (0.25) | (0.21) | (4.61) | NF | (0.30) | (4.82) | ||
Melanoma | SK-MEL-2 | 1.56 | 1.60 | 0.38 | 2.21 | 0.62 | 6.66 | 50.93 | NF | 2.90 | 66.86 |
(0.15) | (0.08) | (0.07) | (0.05) | (0.08) | (0.40) | (5.84) | NF | (0.33) | (6.40) | ||
Melanoma | SK-MEL-5 | 0.38 | 0.38 | 0.13 | 14.84 | 0.52 | 11.64 | 72.02 | NF | 3.83 | 103.75 |
(0.03) | (0.05) | (0.02) | (0.47) | (0.08) | (0.31) | (4.06) | NF | (0.50) | (5.25) | ||
Melanoma | MALME-3M | 0.36 | 0.06 | 0.32 | 3.88 | 0.45 | 1.26 | 94.27 | NF | 1.30 | 101.90 |
(0.03) | (0.01) | (0.05) | (0.26) | (0.06) | (0.05) | (0.88) | NF | (0.13) | (1.13) | ||
Melanoma | M14 | 1.33 | 0.05 | 0.18 | 1.24 | 0.69 | 1.21 | 13.95 | NF | 1.90 | 20.55 |
(0.06) | (0.00) | (0.02) | (0.11) | (0.11) | (0.09) | (0.50) | NF | (0.28) | (0.91) | ||
NSCL | A549 | 0.56 | 0.04 | 0.54 | 1.04 | 1.18 | 2.95 | 17.01 | NF | 2.19 | 25.51 |
(0.06) | (0.00) | (0.05) | (0.05) | (0.07) | (0.27) | (0.86) | NF | (0.24) | (1.18) | ||
NSCL | EKVX | 1.70 | 0.31 | 0.92 | 1.10 | 7.16 | 15.16 | 125.95 | NF | 4.53 | 156.83 |
(0.06) | (0.05) | (0.01) | (0.12) | (0.72) | (1.13) | (13.92) | NF | (0.47) | (12.21) | ||
NSCL | HOP-62 | 1.48 | 0.08 | 0.78 | 2.37 | 4.70 | 6.19 | 25.45 | NF | 13.29 | 54.33 |
(0.24) | (0.01) | (0.14) | (0.40) | (0.44) | (1.18) | (1.85) | NF | (1.56) | (5.04) | ||
NSCL | NCI-H23 | 1.08 | 0.29 | 0.39 | 6.10 | 0.92 | 8.03 | 90.47 | NF | 15.79 | 123.07 |
(0.05) | (0.04) | (0.08) | (0.43) | (0.05) | (0.64) | (2.81) | NF | (2.87) | (3.46) | ||
NSCL | NCI-H460 | 0.18 | 0.05 | 0.15 | 1.36 | 1.15 | 4.03 | 59.76 | 27.89 | 2.21 | 96.78 |
(0.01) | (0.01) | (0.00) | (0.23) | (0.04) | (0.06) | (3.33) | (0.32) | (0.12) | (3.69) | ||
NSCL | NCI-H226 | 0.29 | 0.07 | 0.13 | 0.50 | 0.61 | 25.40 | 181.13 | NF | 21.63 | 229.75 |
(0.02) | (0.01) | (0.01) | (0.02) | (0.07) | (1.05) | (7.48) | NF | (0.69) | (8.87) | ||
NSCL | HOP-92 | 0.33 | 0.03 | 0.43 | 0.55 | 0.24 | 4.87 | 34.58 | NF | 2.20 | 43.24 |
(0.01) | (0.00) | (0.08) | (0.03) | (0.04) | (0.28) | (1.51) | NF | (0.24) | (1.43) | ||
NSCL | NCI-H522 | 0.18 | 0.03 | 0.06 | 1.38 | 0.31 | 4.25 | 32.36 | NF | 1.55 | 40.12 |
(0.02) | (0.00) | (0.01) | (0.08) | (0.04) | (0.36) | (2.39) | NF | (0.31) | (2.58) | ||
NSCL | NCI-H322M | 0.19 | 0.04 | 0.13 | 0.80 | 0.45 | 0.72 | 7.01 | NF | 1.29 | 10.62 |
(0.02) | (0.00) | (0.01) | (0.06) | (0.04) | (0.08) | (0.27) | NF | (0.12) | (0.13) | ||
Ovarian | OVCAR-3 | 0.50 | 0.07 | 0.34 | 0.97 | 3.70 | 5.37 | 26.60 | NF | 5.47 | 43.02 |
(0.05) | (0.01) | (0.04) | (0.09) | (0.54) | (0.73) | (1.63) | NF | (0.81) | (3.21) | ||
Ovarian | OVCAR-5 | 0.16 | 0.03 | 0.13 | 1.26 | 0.33 | 12.85 | 107.47 | NF | 1.57 | 123.79 |
(0.00) | (0.00) | (0.02) | (0.17) | (0.05) | (0.33) | (5.55) | NF | (0.14) | (5.89) | ||
Ovarian | IGR-OV1 | 0.15 | 0.04 | 0.11 | 0.73 | 2.54 | 4.00 | 29.72 | NF | 0.66 | 37.94 |
(0.01) | (0.00) | (0.00) | (0.01) | (0.36) | (0.15) | (0.70) | NF | (0.06) | (1.10) | ||
Ovarian | NCI/ADR-RES | 1.33 | 0.15 | 0.44 | 2.54 | 2.92 | 10.46 | 75.10 | NF | 4.61 | 97.56 |
(0.08) | (0.02) | (0.04) | (0.28) | (0.14) | (0.31) | (0.47) | NF | (0.28) | (0.06) | ||
Ovarian | SK-OV-3 | 1.78 | 0.13 | 0.39 | 0.73 | 0.55 | 12.26 | 132.33 | NF | 4.18 | 152.36 |
(0.23) | (0.02) | (0.03) | (0.09) | (0.10) | (0.25) | (9.43) | NF | (0.63) | (9.94) | ||
Ovarian | OVCAR-8 | 0.44 | 0.13 | 0.15 | 2.10 | 0.35 | 5.12 | 38.83 | NF | 3.61 | 50.73 |
(0.02) | (0.03) | (0.03) | (0.17) | (0.06) | (0.22) | (1.01) | NF | (0.58) | (1.56) | ||
Ovarian | OVCAR-4 | 0.43 | 0.06 | 0.31 | 3.90 | 0.43 | 19.79 | 139.32 | NF | 4.69 | 168.93 |
(0.02) | (0.01) | (0.02) | (0.06) | (0.07) | (1.06) | (2.84) | NF | (0.46) | (2.82) | ||
Prostate | PC-3 | 0.15 | 0.03 | 0.20 | 1.05 | 2.33 | 7.63 | 41.94 | NF | 0.63 | 53.96 |
(0.02) | (0.00) | (0.03) | (0.05) | (0.14) | (0.56) | (2.30) | NF | (0.07) | (2.90) | ||
Prostate | DU145 | 0.55 | 0.04 | 0.42 | 2.22 | 0.71 | 4.94 | 27.78 | NF | 2.55 | 39.22 |
(0.05) | (0.00) | (0.05) | (0.16) | (0.10) | (0.29) | (1.02) | NF | (0.23) | (1.06) | ||
Renal | UO-31 | 0.30 | 0.13 | 0.33 | 1.36 | 1.66 | 5.05 | 22.94 | NF | 2.45 | 34.22 |
(0.03 | (0.02 | (0.02 | (0.26 | (0.26 | (0.60 | (1.18 | NF | (0.15 | (0.92 | ||
Renal | 786-0 | 0.15 | 0.02 | 0.11 | 0.58 | 0.16 | 2.11 | 23.40 | NF | 1.54 | 28.07 |
(0.02) | (0.00) | (0.01) | (0.05) | (0.02) | (0.16) | (0.14) | NF | (0.19) | (0.17) | ||
Renal | SN12C | 0.14 | 0.05 | 0.27 | 6.47 | 1.92 | 4.02 | 25.50 | NF | 0.89 | 39.25 |
(0.01) | (0.01) | (0.02) | (0.29) | (0.17) | (0.07) | (0.97) | NF | (0.05) | (0.96) | ||
Renal | CAKI-1 | 0.54 | 0.16 | 0.13 | 4.76 | 0.49 | 7.57 | 81.60 | NF | 6.52 | 101.77 |
(0.05) | (0.03) | (0.03) | (0.42) | (0.07) | (0.61) | (1.42) | NF | (0.79) | (2.29) | ||
Renal | RXF-393 | 0.27 | 0.03 | 0.09 | 0.47 | 0.44 | 0.34 | 14.48 | NF | 1.41 | 17.54 |
(0.04) | (0.00) | (0.02) | (0.09) | (0.04) | (0.04) | (0.39) | NF | (0.13) | (0.38) | ||
Renal | TK-10 | 0.65 | 0.25 | 0.42 | 2.54 | 0.58 | 7.87 | 37.29 | NF | 6.25 | 55.86 |
(0.06) | (0.04) | (0.02) | (0.24) | (0.06) | (0.22) | (3.96) | NF | (0.60) | (4.27) | ||
Renal | A498 | 0.53 | 0.02 | 0.16 | 0.29 | 0.50 | 3.05 | 37.53 | NF | 2.58 | 44.65 |
(0.04) | (0.00) | (0.00) | (0.03) | (0.07) | (0.29) | (1.09) | NF | (0.37) | (1.45) | ||
Renal | ACHN | 0.43 | 0.08 | 0.19 | 1.25 | 0.39 | 6.17 | 39.27 | NF | 3.40 | 51.17 |
(0.06) | (0.01) | (0.02) | (0.16) | (0.06) | (0.74) | (1.96) | NF | (0.28) | (2.51) |