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Table 3 Prediction of failure to clear of virus on therapy with PegIFN/R with homozygote non-responder SNPs (based on 404 responders and 464 non responders of European origin)

From: Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

Genotype

Sensitivity (95% CI)

Specificity (95% CI)

Positive predictive value (95% CI)

Negative predictive value (95% CI)

rs4803221 GG

8.4 (6.0-11.4)

97.0 (94.7-98.5)

77.1 (62.7-88.0)

47.1 (43.5-50.7)

rs7248668 AA

8.1 (5.7-11.0)

97.3 (95.1-98.7)

78.3 (63.6-89.1)

47.0 (43.4-50.5)

rs8099917 GG

7.4 (5.2-10.3)

96.8 94.5-98.3)

73.3 (58.1-85.4)

46.8 (43.2-50.4)

rs12979860 TT

18.9 (15.4-23.0)

89.5 (85.9-92.5)

68.3 (59.2-76.5)

48.0 (44.2-51.8)