Figure 1
From: MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer
Involvement of miR-221/222 as downstream effectors of the EGFR-RAS-RAF-MEK pathway in progression of metastatic transformation of breast cancer tumors. EGFR, epidermal growth factor receptor; EMT, epithelial-to-mesenchymal transition; ER, estrogen receptor; ERK, extracellular signal-regulated kinase; FOSL1, FOS-like antigen 1; GRB2, growth factor receptor-bound protein 2; MEK, mitogen-activated protein/extracellular signal-regulated kinase kinase; p27Kip1, cyclin-dependent kinase inhibitor p27Kip1; SOS, Son of sevenless homolog; TRPS1, tricho-rhino-phalangeal syndrome type 1; ZEB, zinc finger E-box-binding homeobox.