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Table 1 Prognostic studies in breast cancer looking at HIF-1α and HIF-2α overexpression detected via immunohistochemistry

From: Gene expression and hypoxia in breast cancer

Group

Tumor type

Number of cases

Overall outcome

Association of marker on multivariate analysis

Schindl et al.

[90]

LN+ early BC

206

Unfavorable prognosis for HIF-1α. HIF-2α not assessed

DFS HR = 1.4; P = 0.001

Trastour et al.

[91]

Early BC

132

Unfavorable prognosis for HIF-1α. HIF-2α not assessed

DFS HR = 4.2; P < 0.001

Bos et al. [92]

Stage 1-2 early BC

150

Trend toward unfavorable prognosis for HIF-1α (significant for LN- patients).

HIF-2α not assessed

OS HR = 2.16; P = 0.12

DFS HR = 1.67; P = 0.12

Generali et al. [36]

T2-4 N0-1 early BC

187

Unfavorable prognosis for CAIX. Treatment response for HIF-1α. HIF-2α not assessed

DFS (CAIX) HR = NR; P = 0.02

Clinical response to treatment (HIF-1α): P < 0.05

Gruber et al. [93]

LN+ early BC

77

Trend toward unfavorable prognosis for HIF-1α. HIF-2α not assessed

OS HR = 2.66; P = 0.09

DFS HR = 1.68; P = 0.30

Yamamoto et al. [94]

Early BC

171

Unfavorable prognosis for HIF-1α. HIF-2α not assessed

OS HR = 2.15; P = 0.02

DFS HR = 1.59; P = 0.02

Jubb et al. [3]

Meta-analysis

923

Trend toward unfavorable prognosis for HIF-1α. HIF-2α not assessed

OS HR = 1.80

(95% CI 1.32 to 2.47)

Schoppmann et al. [95]

LN+ early BC

119

Unfavorable prognosis for HIF-1α

OS HR = NR; P = 0.03

DFS HR = NR; P = 0.04

Vleugel et al.

[21]

Early BC

166

Unfavorable prognosis for HIF-1α

DFS HR = 2.23; P = 0.01

Dales et al. [96]

Early BC

745

Unfavorable prognosis for HIF-1α

OS HR = NR; P = 0.030

DFS HR = NR; P = 0.158

Helczynska et al. [97]

Early BC

512

Unfavorable prognosis for HIF-2α. No significant association for HIF-1α

BCSS (HIF-2α) HR = 2.3; P = 0.003

DFS (HIF-2α) HR = 1.6; P = 0.03

  1. BC, breast cancer; BCSS, breast cancer-specific survival; CI, confidence interval; LN+, lymph node positive; LN-, lymph node negative; DFS, disease free survival; HR, hazard ratio; NR, not reported; OS, overall survival.