Figure 4
From: Systems medicine and integrated care to combat chronic noncommunicable diseases
Iterative mathematical modeling to increase knowledge on NCDs. Various targeted or comprehensive data types are collected from samples of individuals with carefully defined phenotypes, processed using probabilistic and network analysis tools, and integrated into predictive models using a knowledge management and simulation platform, leading to the refinement of the classification of NCDs. Mechanistic hypotheses and complex biomarkers of NCDs generated through this process are then tested and validated iteratively using small then large cohorts of independent samples, providing potential diagnostic and therapeutic solutions for the general population.