Regulatory element | Chromatin signature | Cell type | References |
---|---|---|---|
Active promoters | Main: H3K4me3/2. Additional: H3ac, H4ac | General | |
Poised promoters (bivalent) | Main: H3K4me3/2, H3K27me3. Additional: H2AZ, MacroH2A | More prevalent in ESCs/iPSCs | |
Inactive promoters (CpG island-poor) | meC | General | |
Active enhancers | Presence: p300, H3K4me1/2, H3K27ac. Absence: H3K4me3, H3K27me3 | General | |
Poised enhancers | Presence: p300, H3K4me1/2, H3K27me3. Absence: H3K4me3, H3K27ac | Prevalent in hESCs | |
Insulators | CTCF | General | [105] |
Long non-coding RNAs | promoter: H3K4me3. Gene body: H3K36me3 | General | [104] |