Predicting treatment outcome in classical Hodgkin lymphoma: genomic advances

Table 3 Prognostic factors related to the tumor microenvironment

Factor	Cell type	Number of patients	Significance, univariate^a	Significance, multivariate^a	Reference(s)
FOXP3	Treg	926	+ (↑FFS)	+ (↑FFS)	[64]
		257	+ (↑DFS)	NA	[65]
		98	+ (↑FFS)	NA	[50]
		146	-	-	[49]
FOXP3/TIA1	Treg/CD8+ T cells	257	+ (↓EFS, DFS)	+ (↓EFS, DFS)	[65]
GrB	Activated; CD8+ T cells	257	-	-	[65]
		267	+ (↓OS)	+ (↓OS)	[66]
		98	-	-	[50]
		146	-	-	[49]
TIA1	CD8+ T cells	257	+ (↓EFS, DFS)	NA	[65]
		267	+ (↓EFS, DFS, OS)	+ (↓EFS, DFS, OS)	[66]
		146	+ (↓EFS)	-	[49]
		59	+ (↓PFS)	+ (↓PFS)	[48]
FOXP3/GrB	Treg/activated; CD8+ T cells	98	+ (↓FFS, OS)	+ (↓FFS)	[50]
CD68	TAM	166	+ (↓PFS, DFS, DSS)	+ (↓DFS)	[68]
		288	+ (↓EFS, OS)	+ (↓OS)	[70]
FOXP3/CD68	Treg/TAM	122	+ (↓FFS, OS)	NA	[67]
CD20	Background B cells	166	+ (↑PFS)	-	[68]
		146	+(↑EFS)	+ (↑EFS)	[49]

^aThe presence (+) or absence (-) of a significant correlation (positive ↑ or negative ↓) with the study endpoints.
DSS, disease-specific survival; DFS, disease-free survival; EFS, event-free survival; FFS, failure-free survival; FOXP3, forkhead box P3; GrB, granzyme B; HLA, human leukocyte antigen; NA, not applicable; OS, overall survival; PFS, progression-free survival; TAM, tumor-associated macrophage; TIA1, cytotoxic granule-associated RNA-binding protein; Treg, regulatory T cell.

ISSN: 1756-994X