Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics

Tavis, John E; Donlin, Maureen J; Aurora, Rajeev; Fan, Xiaofeng; Di Bisceglie, Adrian M

doi:10.1186/gm222

Table 1 Host genetic factors that affect treatment outcome

From: Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics

Gene symbol	Gene name/description	Polymorphism	Effect on treatment	Reference(s)
IFNλ
IL28B	Interferon, λ3	SNP rs12979860 (C/C)	Twofold increased rate of SVR	[20]
IL28B	Interferon, λ3	SNPs rs8099917 (G) and rs12980275	Associated with non-response	[22]
IL28B	Interferon, λ3	SNP rs809917 (T)	Twofold increased rate of SVR	[21]
Side-effect modulator
ITPA	Inosine triphosphatase	SNPs rs1127354 (A) and rs7270101 (C)	Increased protection against ribavirin-induced anemia	[35–38]
HLA alleles
HLA-A24-B54-DR4	HLA class I/II haplotype	NA	Associated with non-response	[73]
HLA-B54	HLA class I allele	NA	Associated with non-response	[73]
HLA-DRB1*0404	HLA class II allele	NA	Associated with response	[74]
HLA-DRB10701, -DRA1*0201, -DQB1**02	HLA class II haplotype	NA	Associated with response	[75]
HLA-A11, -B51, -CW5 and -DRB1*15	HLA class I and II alleles	NA	Associated with response	[76]
HLA-A24	HLA class I allele	NA	Associated with non-response	[76]
HLA-DRB1*04	HLA class II allele	NA	Associated with non-response to IFN monotherapy	[77]
HLA-DRB1*07	HLA class II allele	NA	Associated with response	[78]
HLA-A33	HLA class I allele	NA	Associated with response	[79]
HLA-DRB1*07	HLA class II allele	NA	Associated with non-response	[80]
HLA-DRB111, -DRB1**0301	HLA class II alleles	NA	Associated with response	[80]
HLA-A24, -B40 -B46	HLA class II alleles	NA	Associated with response	[81]
Other immune-related genes
KIR2DL5	Killer cell immunoglobulin-like receptor	NA	Associated with non-response	[82]
IL6	Interleukin 6	IL6 C174G	Associated with response	[83]
IL10	Interleukin 10	IL10 -592A and -819T	Associated with response	[84, 85]
IL12B	Interleukin 2B	IL12B 3'-UTR 1188C	Associated with response	[86]
MXA	Interferon-inducible protein	MXA -88G and -123A	Response to IFN monotherapy	[87]
CCR5	Chemokine receptor 5	CCR5 -Δ32	Associated with non-response to IFN monotherapy	[88]
CCL5	Chemokine ligand 5, RANTES	CCL5 Int1.1C and 3' 222C	Associated with non-response	[89]
TGFβ	Transforming growth factor β	TGFβ 10T/T, 25G/G and 10T/C, 25 G/G	High producer TGFβ genotype associated with response	[90]
TNFα	Tumor necrosis factor α	TNFα -308A	Associated with response	[91]
IFNγ	Interferon γ	IFNγ -764G	Associated with response	[92]
OPN	Osteopontin	OPN -1748G/G or G/A OPN -443 T/T	Associated with response	[93]
GNB3	Guanine nucleotide-binding protein β polypeptide 3	GNB3 825 C/C	Associated with non-response	[94, 95]
CTLA4	Cytotoxic T-lymphocyte associated protein, T-cell inhibition	CTLA4 -318C -49G haplotype	Associated with response	[96, 97]

HLA, human leukocyte antigen; IFN, interferon; NA, not applicable; SNP, single-nucleotide polymorphism; SVR, sustained viral response; UTR, untranslated region.

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ISSN: 1756-994X

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