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Table 3 Effect estimates of 18 established susceptibility variants on type 2 diabetes risk in two studies

From: Genome-based prediction of common diseases: methodological considerations for future research

  

Odds ratio (95% confidence interval)*

Gene

Locus

GoDARTS study [11]

Rotterdam study [14]

TCF7L2

rs7903146

1.36 (1.24, 1.48)

1.31 (1.19, 1.44)

KCNJ11

rs5219

1.25 (1.15, 1.36)

1.03 (0.93, 1.13)

CDKN2A/2B

rs10811661

1.21 (1.08, 1.35)

1.10 (0.98, 1.24)

PPARG

rs1801282

1.21 (1.07, 1.36)

1.09 (0.95, 1.24)

ADAM30/NOTCH2

rs2641348†

1.15 (1.01, 1.30)

1.01 (0.88, 1.17)

CDKN2A/2B

rs564398‡

1.13 (1.04, 1.22)

1.04 (0.95, 1.14)

IGF2BP2

rs4402960

1.12 (1.03, 1.22)

1.11 (1.01, 1.22)

FTO

rs8050136

1.11 (1.02, 1.20)

1.09 (0.99, 1.19)

CDKAL1

rs10946398§

1.11 (1.02, 1.21)

1.11 (1.02, 1.22)

SLC30A8

rs13266634

1.10 (1.01, 1.20)

1.13 (1.02, 1.24)

TSPAN8/LGR5

rs7961581¶

1.09 (1.00, 1.19)

1.09 (0.99, 1.20)

CDC123

rs12779790Â¥

1.10 (0.99, 1.21)

0.95 (0.84, 1.06)

WFS1

rs10010131**

1.07 (0.99, 1.16)

1.12 (1.05, 1.27)

TCF2

rs757210††

1.07 (0.99, 1.16)

0.93 (0.85, 1.02)

ADAMTS9

rs4607103‡‡

1.05 (0.96, 1.16)

1.14 (1.03, 1.28)

HHEX-IDE

rs1111875

1.02 (0.94, 1.11)

1.06 (0.97, 1.15)

THADA

rs7578597

1.04 (0.90, 1.19)

1.10 (0.96, 1.27)

JAZF1

rs864745§S

1.00 (0.93, 1.09)

1.09 (1.00, 1.19)

  1. *AUC (area under the receiver operating characteristic curve) was 0.60 for both studies. Values were obtained using logistic regression analyses. For several genes, the Rotterdam study [14] uses different single nucleotide polymorphisms from those listed: ‡‡rs4411878, r2 = 0.95; ¥rs11257622; r2 = 0.83; ‡rs1412829, r2 = 0.97; §Srs1635852, r2 = 0.97; †rs1493694; ¶rs1353362, r2 = 0.96; ††rs4430796, r2 = 0.61; **rs10012946, r2 = 1.00; §rs7754840, r2 = 1.00. Statistically significant associations are presented in bold and r2 is a measure of linkage disequilibrium.