Table 2 Functional siRNA screening data for 11 GBM survival-associated genes in the A172 glioblastoma cell line
From: Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
Symbol | Description | siRNA name | CTG | Caspase | Survival | Expression |
|---|---|---|---|---|---|---|
AllStars Cell Death Vontrol siRNA (Cell death ctrl) | -13.80 | 19.62 | NA | NA | ||
AllStars Negative Control siRNA (siNEG) | 0.00 | 0.00 | NA | NA | ||
KIF11 | Kinesin family member 11 | KIF11_7 | -9.56 | 7.39 | NA | NA |
PLK1 | Polo-like kinase 1 | PLK1_7 | -5.92 | 0.31 | NA | NA |
FLNC | Filamin C, gamma | FLNC_2 | 2.56 | -0.89 | 0.000189 | 2.51 |
FLNC_5 | -0.37 | 0.29 | ||||
FLNC_6 | -0.57 | -0.94 | ||||
FLNC_7 | -5.39 | 0.49 | ||||
H19 | H19, imprinted | H19_1 | 0.38 | -0.14 | 0.000588 | 3.54 |
maternally expressed | H19_2 | -5.08 | 1.17 | |||
transcript (non-protein | H19_3 | 5.20 | -2.71 | |||
coding) | H19_4 | -2.97 | 2.71 | |||
HIST1H4L | Histone cluster 1, H4l | HIST1H4L_1 | 1.63 | -0.60 | 0.001560 | 5.01 |
HIST1H4L_2 | 2.61 | -2.00 | ||||
HIST1H4L_5 | -0.36 | -1.19 | ||||
HIST1H4L_7 | -5.93 | -0.97 | ||||
KIAA0040 | KIAA0040 | KIAA0040_11 | -2.94 | -0.64 | 0.000867 | 2.63 |
KIAA0040_12 | 0.63 | -0.83 | ||||
LOC100129443_3 | 0.69 | -0.71 | ||||
LOC100129443_4 | -0.31 | -0.30 | ||||
LTF | Lactotransferrin | LTF_1 | -1.74 | 0.22 | 0.001570 | 3.95 |
LTF_2 | -0.03 | 0.07 | ||||
LTF_5 | -1.04 | 0.44 | ||||
LTF_6 | -1.18 | -0.79 | ||||
NNMT | Nicotinamide N- | NNMT_5 | -0.91 | -1.29 | 0.000074 | 7.41 |
methyltransferase | NNMT_6 | -0.48 | -1.87 | |||
NNMT_7 | -1.26 | -0.32 | ||||
NNMT_8 | -0.30 | -0.10 | ||||
POSTN | Periostin, osteoblast | POSTN_1 | 0.24 | -1.16 | 0.001950 | 14.9 |
specific factor | POSTN_2 | 0.28 | -2.11 | |||
POSTN_6 | -2.17 | 0.56 | ||||
POSTN_7 | 0.52 | 0.12 | ||||
TAGLN2 | Transgelin 2 | TAGLN2_10 | 4.53 | -1.74 | 0.001010 | 4.21 |
TAGLN2_11 | -3.78 | 0.48 | ||||
TAGLN2_8 | -0.43 | 0.45 | ||||
TAGLN2_9 | 4.67 | -1.94 | ||||
TIMP1 | TIMP metallopeptidase | TIMP1_2 | -0.09 | -0.96 | 0.000109 | 3.21 |
inhibitor 1 | TIMP1_4 | 1.07 | 0.88 | |||
TIMP1_5 | 0.56 | -1.87 | ||||
TIMP1_6 | -0.08 | 0.41 | ||||
MSN | Moesin | MSN_8 | -1.68 | 1.61 | 0.000028 | 3.42 |
MSN_9 | -4.49 | -1.05 | ||||
MSN_5 | -0.36 | -1.57 | ||||
MSN_1 | -2.57 | 0.80 | ||||
CDKN2A | Cyclin-dependent kinase inhibitor 2A | NA (gene deleted in A172) | ||||