Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned

Table 3 Functional SNPs associated with ischemic stroke

System	Gene	Polymorphism	References
Lipid metabolism	APOA5 (*606368)	g.-1131T > C, c.1259T > C, c.56C > G, c.IVS3+476G > A	[82–88]
	APOCIII (*107720)	g.-2854T > G, g.-455C > T, g.-482C > T, c.3238C > G	[73–76]
	LPL (*609708)	p.Asn291Ser	[92–95]
	GCKR (*600842)	c.1337C > T	[104]
	MLXIPL (*605678)	rs17145738, rs3812316	[105]
	GALNT (*602274)	rs4846914	[104]
Signal transduction	PDE4D (*600129)	Six SNPs, haplotypes	[96–100]
Inflammation	ALOX5AP (*603700)	Seven SNPs, haplotypes	[97, 100–103]

ALOX5AP, arachidonate 5-lipoxygenase-activating protein; APOA5, apolipoprotein A5; APOCIII, apolipoprotein CIII; LPL, lipoprotein lipase; PDE4D, phosphodiesterase 4D.

ISSN: 1756-994X