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Table 2 Genes and their polymorphisms associated with ischemic stroke in GWASs

From: Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned

System

Gene

Polymorphism

References

Hemostasis

Factor II (prothrombin) (+176930)

c.20210G > A

[39, 41–43]

 

Factor V (Leiden) (*612309)

p.Arg506Gln

[33–40]

 

Factor XIII (+134570)

p.Val34Leu

[39, 44, 45]

Renin-angiotensin system

ACE (+106180)

Insertion/deletion

[40, 48–51]

 

AT1R (*106165)

c.1166A > C

[52–55]

Nitric-oxide-synthase system

eNOS (+163729)

p.Glu298Asp

[56–58]

Homocysteine metabolism

MTHFR (*607093)

c.677C > T and c.1298A > C

[43, 59–61]

Lipid metabolism

APOE (+107741)

ε4, ε3, ε2

[40, 46, 62–66]

  1. ACE, angiotensin converting enzyme; APOE, apolipoprotein E; AT1R, angiotensin-receptor; eNOS, endothelial nitric oxide synthase; MTHFR, 5,10-methylenetetrahydrofolate reductase.
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Genome Medicine

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