Potential mechanisms of sunitinib resistance |
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   Hypoxia resistance of RCC cells |
   Vascular resistance to VEGFR and PDGFR inhibition by sunitinib |
Potential mechanisms of everolimus resistance |
   Resistance of RCC cells to direct anti-proliferative everolimus effects |
   Resistance of HIF1α target gene expression to repression by everolimus |
   Hypoxia resistance of RCC cells |
   Vascular resistance to VEGF pathway inhibition |