Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?

Wiklund, Fredrik

doi:10.1186/gm166

Table 1 Established prostate cancer susceptibility alleles

From: Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?

dbSNP number	Chromosome	Gene^a	Risk allele^b	Study
rs1465618	2p21	THADA	A	Eeles et al. 2009 [21]
rs721048	2p15	EHBP1	A	Gudmundsson et al. 2008 [27]
rs12621278	2q31.1	ITGA6	A	Eeles et al. 2009 [21]
rs4857841	3q21.3	EEFSEC	A	Gudmundsson et al. 2009 [57]
rs12500426	4q22.3	PDLIM5	A	Eeles et al. 2009 [21]
rs17021918	4q22.3	PDLIM5	C	Eeles et al. 2009 [21]
rs7679673	4q24	FLJ20032	C	Eeles et al. 2009 [21]
rs9364554	6q25.3	SLC22A3	T	Eeles et al. 2008 [28]
rs10486567	7p15.2	JAZF1	G	Thomas et al. 2008 [26]
rs6465657	7q21.3	LMTK2	C	Eeles et al. 2008 [28]
rs1512268	8p21.2	NKX3-1	T	Eeles et al. 2009 [21]
rs12543663	8q24.21		C	Al Olama et al. 2009 [16]
rs10086908	8q24.21		T	Al Olama et al. 2009 [16]
rs1016343	8q24.21		T	Al Olama et al. 2009 [16]
rs13252298	8q24.21		A	Al Olama et al. 2009 [16]
rs6983561	8q24.21		C	Al Olama et al. 2009 [16]
rs16901979	8q24.21		A	Gudmundsson et al. 2007 [11]
rs16902094	8q24.21		G	Gudmundsson et al. 2009 [57]
rs445114	8q24.21		T	Gudmundsson et al. 2009 [57]
rs620861	8q24.21		C	Al Olama et al. 2009 [16]
rs6983267	8q24.21		G	Al Olama et al. 2009 [16]
rs1447295	8q24.21		A	Amundadottir et al. 2006 [9]
rs10993994	10q11.23	MSMB	T	Eeles et al. 2008 [28]
rs4962416	10q26.13	CTBP2	C	Thomas et al. 2008 [26]
rs7127900	11p15.5		A	Eeles et al. 2009 [21]
rs12418451	11q13.2		A	Zheng et al. 2009 [34]
rs11228565	11q13.2		A	Gudmundsson et al. 2009 [57]
rs10896449	11q13.2		G	Thomas et al. 2008 [26]
rs11649743	17q12	HNF1B	G	Sun et al. 2008 [30]
rs4430796	17q12	HNF1B	A	Gudmundsson et al. 2007 [11]
rs1859962	17q24.3		G	Gudmundsson et al. 2007 [11]
rs8102476	19q13.2	PPP1R14A	C	Gudmundsson et al. 2009 [57]
rs2735839	19q13.33	KLK3	A	Eeles et al. 2008 [28]
rs9623117	22q13.1	TNRC6B	C	Sun et al. 2009 [31]
rs5759167	22q13.2	BIK	G	Eeles et al. 2009 [21]
rs5945619	Xp11.22	NUDT11	C	Eeles et al. 2008 [28]

^aGenes within the linkage-disequilibrium block defined by the associated variant: BIK, BCL2-interacting killer; CTBP2, C-terminal binding protein 2 isoform 2; EEFSEC, elongation factor for selenoprotein translation; EHBP1, EH domain binding protein 1; FLJ20032, hypothetical protein LOC54790; HNF1B, hepatocyte nuclear factor 1 homeobox B; ITGA6, integrin alpha chain 6; JAZF1, juxtaposed with another zinc finger gene 1; KLK3, kallikrein 3; LMTK2, lemur tyrosine kinase 2; MSMB, β-microseminoprotein isoform a precursor; NKX3-1, NK3 transcription factor related locus 1; NUDT11, nudix-type motif 11; PDLIM5, PDZ and LIM domain 5 isoform d; PPP1R14A, protein phosphatase 1 regulatory inhibitor; SLC22A3, solute carrier family 22 member 3; SLC25A37, mitochondrial solute carrier protein; THADA, thyroid adenoma associated isoform 1; TNRC6B, trinucleotide repeat containing 6B isoform 2. ^bRisk alleles as defined from published data cited in the column.

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