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Table 1 Results of 11 single nucleotide polymorphisms selected for the risk model in the combined analysis of QTSCD and QTGEN

From: Novel genes for QTc interval. How much heritability is explained, and how much is left to find?

Locus

Chromosome

Variant

Coded allele

Beta

Standard error

Pvalue

RNF207

1

rs846111

C

1.70

0.21

3.69 × 10-16

NOS1AP

1

rs12143842

T

3.27

0.17

1.88 × 10-78

ATP1B1

1

rs10919071

A

1.78

0.22

1.20 × 10-15

SCN5A

3

rs12053903

C

-1.23

0.12

1.0 × 10-14

PLN; C6orf204

6

rs11970286

T

1.53

0.15

2.35 × 10-24

KCNH2

7

rs4725982

T

1.44

0.16

5.0 × 10-16

KCNQ1

11

rs12296050

T

1.62

0.19

2.80 × 10-17

LITAF

16

rs8049607

T

1.34

0.17

5.78 × 10-15

NDRG4; CNOT1

16

rs37062

G

-1.68

0.16

3.0 × 10-25

LIG3

17

rs2074518

T

-1.05

0.12

6.0 × 10-12

KCNJ2

17

rs17779747

T

-1.10

0.16

6.02 × 10-12

  1. The KCNE1 non-synonymous D85N variant rs1805128 (see also Figure 2) was not included in our risk score. It was genome-wide significant in the QTGEN study, but could not be confirmed in the QTSCD study and the combined analysis due to limited genotyping coverage in QTSCD.
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Genome Medicine

ISSN: 1756-994X

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