Table 3 Predicted biological functions from Ingenuity Pathways Analysis
| Â | P-value | Number of genes | Genes |
|---|---|---|---|
Diseases and disorders | Â | Â | Â |
   Neurological disease | 1.38E-03 to 1.89E-02 | 8 | UCHL1,ATF3,NDP,TUBB2C,KIF1B,TUBB2A,MST1,BCL2 |
   Inflammatory disease | 2.51E-03 to 2.11E-02 | 16 | IL6ST,ADM,TUBB2C,IL32,PIK3R1,TUBB2A,EIF1,ALOX5AP,MMP10,DUSP2,BCL2,GNAI2,HSPA8,FUT8,LDLR,AHNAK |
   Skeletal and muscular disorders | 2.71E-03 to 1.89E-02 | 16 | IL6ST,ADM,COL6A2,TUBB2C,IL32,TUBB2A,ALOX5AP,MMP10,LARGE,DUSP2,BCL2,GNAI2,HSPA8,CEP290,BMI1,AHNAK |
Molecular and cellular functions | Â | Â | Â |
   Lipid metabolism | 1.19E-04 to 2.51E-02 | 13 | ADM,IL6ST,ABCG5,ABHD5,IL32,PIK3R1,ALOX5AP,BCL2,GNAI2,IFRD1,LDLR,PRKAR2B,PITPNC1 |
   Molecular transport | 1.19E-04 to 2.51E-02 | 12 | IL6ST,IFRD1,HSPA8,GNAI2,ABHD5,ABCG5,LDLR,PIK3R1,IL32,PITPNC1,ALOX5AP,BCL2 |
   Small molecule biochemistry | 1.19E-04 to 2.51E-02 | 17 | IL6ST,ADM,AMPD3,ABCG5,ABHD5,PIK3R1,ASS1,IL32,ALOX5AP,BCL2,IFRD1,GNAI2,BCAT1,LDLR,PITPNC1,GOT1,GLDC |
   Cellular development | 1.32E-04 to 2.42E-02 | 13 | IL6ST,ATF3,PIK3R1,ID3,BCL2,IGLL1,IFRD1,ELF3,BMI1,PRKAR2B,PLK2,LAMA1,PLAC8 |
   Cell death | 2.36E-04 to 1.89E-02 | 14 | IL6ST,ADM,ATF3,DDIT4,PIK3R1,NCK1,PSIP1,SH3BP5,ID3,BCL2,PRKAR2B,BMI1,PLK2,PLAC8 |
Canonical pathways | Â | Â | Â |
   Nitric oxide signaling | 1.07E-02 | 3/90 | CACNA1E,PRKAR2B,PIK3R1 |
   VEGF signaling | 1.47E-02 | 3/92 | PIK3R1,EIF1,BCL2 |
   Amyotrophic lateral sclerosis signaling | 1.88E-02 | 3/108 | CACNA1E,PIK3R1,BCL2 |
Toxicity list | Â | Â | Â |
   Hormone receptor regulated cholesterol metabolism | 4.96E-02 | 1/8 | LDLR |