Non-coding RNAs: a key to future personalized molecular therapy?

Table 4 Overview of in vivo delivery systems for snoRNAs and miRNAs*

miRNA	Disease state	Biological target	*In vivo*model	Delivery system	References
miR-100	Nasopharyngeal cancer	Plk1	6- to 8-week-old SCID BALB/c female mice	siRNA and ionizing radiation and potential miRNAs that might regulate Plk1 expression	[88]
Synthetic miR-16	Metastatic prostate cancer	CDK1 and CDK2	Bone metastasis mode mice	Injected into tail veins	[89]
miR-155	Myeloproliferative disorder	SHIP1	Mice, specific knockdown of SHIP1 in the hematopoietic system	Retroviral delivery of a miR-155-formatted siRNA against SHIP1	[90]
SNORD116 (PWCR1/HBII-85)	Prader-Willi syndrome	Bioinformatic screen located 23 possible targets	C57BL/6 mice	Snord116del mice	[21]
miR-147	Inflammation	Cytokine expression in macrophages stimulated with ligands to Toll-like receptors: TLR2, TLR3, TLR4	LPS-stimulated mouse	Peritoneal macrophages were transfected with 40 nM control miRNA mimics or mouse miR-147 mimics	[91]
LNA-antimiR-122	Hypercholesterolemia	miR-122 liver specific	Normal and hypercholesterolemic mice; normal African green monkeys	Intravenous injections unconjugated	[62]
LNA-antimiR-21	Glioma	miR-21	Athymic nude mice	Intracranial cell implantation	[92]
miR-34a	Normal	E2F family	Nude mice	Subcutaneous administration of miR-34a/collagen complexes	[93]
mir-17-92 cluster	Normal	c-Myc	Mice reconstituted with hematopoietic stem cells expressing mir-17-19b	Perfusion cells treated by retroviral vector	[94]

*Abbreviations: CDK, cyclin-dependent kinase; E2F, E2 transcription factor; LPS, lipopolysaccharide; Plk1, Polo-like kinase 1; SCID, severe combined immunodeficient; SHIP1, Src homology-2 domain-containing inositol 5-phosphatase 1; TLR, Toll-like receptor.

ISSN: 1756-994X