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Figure 1 | Genome Medicine

Figure 1

From: Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

Figure 1

OXPHOS gene expression and relationship to disease status. (a) Plot of median intensity of OXPHOS probes (red circles) for NGT (n = 47) versus T2D (DM; n = 45) on the background of absent filtered probesets (black circles). The insert shows the mean expression of OXPHOS probesets (± standard error of the mean). (b) Plot of median intensity of OXPHOS probes (red circles) for NGT (n = 14) versus T2D (n = 17) on the background of absent filtered probesets (black circles). These subjects have the same physiological characteristics as those in the Mootha et al. study [1]. The insert shows the mean expression of OXPHOS probesets (± standard error of the mean). (c) Correlation plot for HOMA2 insulin resistance (IR) and MAS 5.0 normalized expression values for the OXPHOS probe sets. Each point represents the median expression for an OXPHOS probe set after filtering the Affymetrix data as described above. The subject groups are represented by colored points: black = normal glucose tolerance; green = impaired glucose tolerance; red = type 2 diabetic. The regression line is shown in black along with the R squared value for goodness of fit and the P-value indicating significance of the relationship. (d) The linear correlation between 2 hour blood glucose (during oral glucose tolerance test) and PGC-1α expression (n = 118) in skeletal muscle of subjects across the clinical groups NGT (black-dots), IGT (green-dots) and T2D (red-dots) derived from the Affymetrix probe set. The regression line is shown in black along with the R squared value for goodness of fit and the P-value indicating significance of the relationship.

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