Table 4 KEGG pathways having two or more quantitated proteins for which evidence of differential change between baseline to 1-year concentration with E+P and E-alone was significant, with FDR < 0.05

Porphyrin and chlorophyll metabolism

2

<0.001

<0.001

Dorsoventral axis formation

4

<0.001

<0.001

Motor signaling pathway

2

0.002

0.009

Pancreatic cancer

2

0.002

0.009

Focal adhesion

14

0.003

0.011

Bladder cancer

3

0.005

0.015

Renal cell carcinoma

3

0.009

0.023

Notch signaling pathway

5

0.011

0.024

Ether lipid metabolism

2

0.012

0.024

Long term depression

2

0.022

0.039

Regulation of actin cytoskeleton

8

0.025

0.041

Cytokine-cytokine receptor interaction

21

0.032

0.048

E-alone pathway

Porphyrin and chlorophyll metabolism

2

<0.001

<0.001

GNRH signaling pathway

2

<0.001

<0.001

Ether lipid metabolism

2

0.001

0.011

Bladder cancer

3

0.002

0.016