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Figure 1 | Genome Medicine

Figure 1

From: Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversies

Figure 1

Mitochondrial energy metabolism. Fatty acid β-oxidation and the TCA cycle produce NADH and FADH2, which are oxidized by complexes I and II, respectively, of the electron transport chain. Electrons are transferred through the chain to the final acceptor, O2. The free energy from electron transfer is used to pump H+ out of the mitochondria and generate an electrochemical gradient, ΔμH+, across the inner mitochondrial membrane. This gradient is the driving force for ATP synthesis via the ATP synthase.

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