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Figure 2 | Genome Medicine

Figure 2

From: Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor δ from Peroxisome proliferator-activated receptor γ in the ob/obmouse

Figure 2

Multivariate analysis of selected GC-MS analysis of key metabolic changes in liver, skeletal muscle and adipose tissue. (a) PLS-DA scores plot showing the clustering of GC-MS chromatograms from the organic fraction of the liver from mice treated with either a PPARδ or a PPARγ agonist compared with the control group. Circle, PPARδ agonist treated; diamond, PPARγ agonist treated; square, control (R2 = 0.59, Q2 = 0.82). (b) PLS-DA scores plot showing the clustering of GC-MS chromatograms from the aqueous phase of skeletal muscle extracts from mice treated with either a PPARδ agonist or a PPARγ agonist compared with control animals. Circle, PPARδ agonist treated; diamond, PPARγ agonist treated; square, control (R2 = 0.24, Q2 = 0.32). (c) PLS-DA scores plot showing clustering of GC-MS chromatograms from the organic fraction of white adipose tissue from PPARδ agonist and PPARγ agonist treated mice following GC-MS analysis. Circle, PPARδ agonist treated; diamond, PPARγ agonist treated; square, control (R2 = 0.58, Q2 = 0.50).

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